KEGG   NETWORK: N01870
Entry
N01870                      Network                                
Name
HIF-2A signaling pathway
Definition
EPAS1 == ARNT => (VEGFA,CXCL8,GLUT1,EPO)
  Expanded
2034 == 405 => (7422,3576,6513,2056)
Class
nt06542 HIF signaling
Type
Reference
Gene
2034  EPAS1; endothelial PAS domain protein 1
405  ARNT; aryl hydrocarbon receptor nuclear translocator
7422  VEGFA; vascular endothelial growth factor A
3576  CXCL8; C-X-C motif chemokine ligand 8
6513  SLC2A1; solute carrier family 2 member 1
2056  EPO; erythropoietin
Reference
PMID:36630072
  Authors
Choi WW, Boland JL, Kalola A, Lin J
  Title
Belzutifan (MK-6482): Biology and Clinical Development in Solid Tumors.
  Journal
Curr Oncol Rep 25:123-129 (2023)
DOI:10.1007/s11912-022-01354-5
Reference
PMID:38344974
  Authors
Chan KH, Li N, Lador R, Amsbaugh M, Gonzalez A, Cen P
  Title
Belzutifan, HIF-2alpha Inhibitor, and Clear Cell Renal Cell Carcinoma With Somatic Von-Hippel-Lindau Loss-of-Function Mutation.
  Journal
J Investig Med High Impact Case Rep 12:23247096241231641 (2024)
DOI:10.1177/23247096241231641
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