KEGG   NETWORK: N01877
Entry
N01877                      Network                                
Name
ERBB4 mutation to GF-RTK-PI3K signaling pathway
Definition
NRG // ERBB4*
  Expanded
(3084,9542,10718,145957) // 2066v1
Class
nt06543 NRG-ERBB signaling
Type
Variant
Pathway
hsa04012  ErbB signaling pathway
Disease
H00058 Amyotrophic lateral sclerosis (ALS)   
Gene
3084  NRG1; neuregulin 1
9542  NRG2; neuregulin 2
10718  NRG3; neuregulin 3
145957  NRG4; neuregulin 4
2066  ERBB4; erb-b2 receptor tyrosine kinase 4
Reference
  Authors
Mei L, Nave KA
  Title
Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases.
  Journal
Neuron 83:27-49 (2014)
DOI:10.1016/j.neuron.2014.06.007
Reference
  Authors
Takahashi Y, Fukuda Y, Yoshimura J, Toyoda A, Kurppa K, Moritoyo H, Belzil VV, Dion PA, Higasa K, Doi K, Ishiura H, Mitsui J, Date H, Ahsan B, Matsukawa T, Ichikawa Y, Moritoyo T, Ikoma M, Hashimoto T, Kimura F, Murayama S, Onodera O, Nishizawa M, Yoshida M, Atsuta N, Sobue G, Fifita JA, Williams KL, Blair IP, Nicholson GA, Gonzalez-Perez P, Brown RH Jr, Nomoto M, Elenius K, Rouleau GA, Fujiyama A, Morishita S, Goto J, Tsuji S
  Title
ERBB4 mutations that disrupt the neuregulin-ErbB4 pathway cause amyotrophic lateral sclerosis type 19.
  Journal
Am J Hum Genet 93:900-5 (2013)
DOI:10.1016/j.ajhg.2013.09.008
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