Homo sapiens (human): 9542
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Entry
9542 CDS
T01001
Symbol
NRG2, DON1, HRG2, NTAK
Name
(RefSeq) neuregulin 2
KO
K05456
neuregulin 2
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa04012
ErbB signaling pathway
hsa05014
Amyotrophic lateral sclerosis
Network
nt06464
Amyotrophic lateral sclerosis
nt06530
PI3K signaling
nt06543
NRG-ERBB signaling
Element
N01163
NRG-ERBB4-PI3K signaling pathway
N01164
Mutation-inactivated ERBB4 to NRG-ERBB4-PI3K signaling pathway
N01656
GF-RTK-PI3K signaling pathway
N01658
GF-RTK-RAS-PI3K signaling pathway
N01874
NRG-ERBB2/ERBB3 pathway (RAS-ERK signaling)
N01875
NRG-ERBB2/ERBB3 pathway (P13K signaling)
N01877
ERBB4 mutation to GF-RTK-PI3K signaling pathway
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
9542 (NRG2)
09160 Human Diseases
09164 Neurodegenerative disease
05014 Amyotrophic lateral sclerosis
9542 (NRG2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
9542 (NRG2)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04052 Cytokines and neuropeptides [BR:
hsa04052
]
9542 (NRG2)
Cytokines and neuropeptides [BR:
hsa04052
]
Cytokines
Growth factors (RTK binding)
9542 (NRG2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Neuregulin
I-set
Ig_3
ig
Ig_2
Ig_6
V-set
C2-set_2
EGF
EGF_2
DUF6377
Motif
Other DBs
NCBI-GeneID:
9542
NCBI-ProteinID:
NP_004874
OMIM:
603818
HGNC:
7998
Ensembl:
ENSG00000158458
UniProt:
O14511
LinkDB
All DBs
Position
5:complement(139846781..140043299)
Genome browser
AA seq
850 aa
AA seq
DB search
MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA
APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV
QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI
SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK
KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK
VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY
YIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKAEELYQKRVLTITGICVALLVVG
IVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPA
TDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLS
SVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPA
RLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGP
GPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECA
PPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDD
ADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPP
PRAKQDSAPL
NT seq
2553 nt
NT seq
+upstream
nt +downstream
nt
atgcggcaggtttgctgctcagcgctgccgccgccgccactggagaagggtcggtgcagc
agctacagcgacagcagcagcagcagcagcgagaggagcagcagcagcagcagcagcagc
agcgagagcggcagcagcagcaggagcagcagcaacaacagcagcatctctcgtcccgct
gcgcccccagagccgcggccgcagcaacagccgcagccccgcagccccgcagcccggaga
gccgccgcccgttcgcgagccgcagccgccggcggcatgaggcgcgacccggcccccggc
ttctccatgctgctcttcggtgtgtcgctcgcctgctactcgcccagcctcaagtcagtg
caggaccaggcgtacaaggcacccgtggtggtggagggcaaggtacaggggctggtccca
gccggcggctccagctccaacagcacccgagagccgcccgcctcgggtcgggtggcgttg
gtaaaggtgctggacaagtggccgctccggagcggggggctgcagcgcgagcaggtgatc
agcgtgggctcctgtgtgccgctcgaaaggaaccagcgctacatctttttcctggagccc
acggaacagcccttagtctttaagacggcctttgcccccctcgataccaacggcaaaaat
ctcaagaaagaggtgggcaagatcctgtgcactgactgcgccacccggcccaagttgaag
aagatgaagagccagacgggacaggtgggtgagaagcaatcgctgaagtgtgaggcagca
gccggtaatccccagccttcctaccgttggttcaaggatggcaaggagctcaaccgcagc
cgagacattcgcatcaaatatggcaacggcagaaagaactcacgactacagttcaacaag
gtgaaggtggaggacgctggggagtatgtctgcgaggccgagaacatcctggggaaggac
accgtccggggccggctttacgtcaacagcgtgagcaccaccctgtcatcctggtcgggg
cacgcccggaagtgcaacgagacagccaagtcctattgcgtcaatggaggcgtctgctac
tacatcgagggcatcaaccagctctcctgcaaatgtccaaatggattcttcggacagaga
tgtttggagaaactgcctttgcgattgtacatgccagatcctaagcaaaaagccgaggag
ctgtaccagaagagggtcctgaccatcacgggcatctgcgtggctctgctggtcgtgggc
atcgtctgtgtggtggcctactgcaagaccaaaaaacagcggaagcagatgcacaaccac
ctccggcagaacatgtgcccggcccatcagaaccggagcttggccaatgggcccagccac
ccccggctggacccagaggagatccagatggcagattatatttccaagaacgtgccagcc
acagaccatgtcatcaggagagaaactgagaccaccttctctgggagccactcctgttct
ccttctcaccactgctccacagccacacccacctccagccacagacacgagagccacacg
tggagcctggaacgttctgagagcctgacttctgactcccagtcggggatcatgctatca
tcagtgggtaccagcaaatgcaacagcccagcatgtgtggaggcccgggcaaggcgggca
gcagcctacaacctggaggagcggcgcagggccaccgcgccaccctatcacgattccgtg
gactcccttcgcgactccccacacagcgagaggtacgtgtcggccctgaccacgcccgcg
cgcctctcgcccgtggacttccactactcgctggccacgcaggtgccaactttcgagatc
acgtcccccaactcggcgcacgccgtgtcgctgccgccggcggcgcccatcagttaccgc
ctggccgagcagcagccgttactgcggcacccggcgccccccggcccgggacccggaccc
gggcccgggcccgggcccggcgcagacatgcagcgcagctatgacagctactattacccc
gcggcggggcccggaccgcggcgcgggacctgcgcgctcggcggcagcctgggcagcctg
cctgccagccccttccgcatccccgaggacgacgagtacgagaccacgcaggagtgcgcg
cccccgccgccgccgcggccgcgcgcgcgcggtgcgtcccgcaggacgtcggcggggccc
cggcgctggcgccgctcgcgcctcaacgggctggcggcgcagcgcgcacgggcggcgagg
gactcgctgtcgctgagcagcggctcgggcggcggctcagcctcggcgtcggacgacgac
gcggacgacgcggacggggcgctggcggccgagagcacacctttcctgggcctgcgtggg
gcgcacgacgcgctgcgctcggactcgccgccactgtgcccggcggccgacagcaggact
tactactcactggacagccacagcacgcgggccagcagcagacacagccgcgggccgccc
ccgcgggccaagcaggactcggcgccactctag
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