KEGG   NETWORK: N01878
Entry
N01878                      Network                                
Name
Glutamate-GRM-GNAQ/S signaling pathway
Definition
Glutamate -> GRM1/5 -> (GNAQ,GNAS) -> (PLCB,ADCY)
  Expanded
C00025 -> (2911,2915) -> (2776,2778) -> ((23236,5330,5331,5332),(107,108,109,196883,111,112,113,114,115))
Class
nt06544 Neuroactive ligand signaling
Type
Reference
Pathway
hsa04724  Glutamatergic synapse
hsa04082  Neuroactive ligand signaling
Gene
2911  GRM1; glutamate metabotropic receptor 1
2915  GRM5; glutamate metabotropic receptor 5
2776  GNAQ; G protein subunit alpha q
2778  GNAS; GNAS complex locus
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
107  ADCY1; adenylate cyclase 1
108  ADCY2; adenylate cyclase 2
109  ADCY3; adenylate cyclase 3
196883  ADCY4; adenylate cyclase 4
111  ADCY5; adenylate cyclase 5
112  ADCY6; adenylate cyclase 6
113  ADCY7; adenylate cyclase 7
114  ADCY8; adenylate cyclase 8
115  ADCY9; adenylate cyclase 9
Metabolite
C00025  L-Glutamate
Reference
PMID:17706608
  Authors
Gass JT, Olive MF
  Title
Glutamatergic substrates of drug addiction and alcoholism.
  Journal
Biochem Pharmacol 75:218-65 (2008)
DOI:10.1016/j.bcp.2007.06.039
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