| Entry |
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| Name |
GABA-GABBR-GNAI/O signaling pathway
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| Definition |
GABA -> GABBR -> (GNAI,GNAO) -| ADCY |
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| Expanded |
C00334 -> (2550,9568) -> ((2770,2771,2773),2775) -| (107,108,109,196883,111,112,113,114,115) |
|---|
| Class |
nt06544 Neuroactive ligand signaling
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| Type |
Reference
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| Pathway |
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| Gene |
| 2550 | GABBR1; gamma-aminobutyric acid type B receptor subunit 1 |
| 9568 | GABBR2; gamma-aminobutyric acid type B receptor subunit 2 |
| 2770 | GNAI1; G protein subunit alpha i1 |
| 2771 | GNAI2; G protein subunit alpha i2 |
| 2773 | GNAI3; G protein subunit alpha i3 |
| 2775 | GNAO1; G protein subunit alpha o1 |
| 107 | ADCY1; adenylate cyclase 1 |
| 108 | ADCY2; adenylate cyclase 2 |
| 109 | ADCY3; adenylate cyclase 3 |
| 196883 | ADCY4; adenylate cyclase 4 |
| 111 | ADCY5; adenylate cyclase 5 |
| 112 | ADCY6; adenylate cyclase 6 |
| 113 | ADCY7; adenylate cyclase 7 |
| 114 | ADCY8; adenylate cyclase 8 |
| 115 | ADCY9; adenylate cyclase 9 |
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| Metabolite |
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| Reference |
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| Authors |
Cooper MS, Przebinda AS |
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| Title |
Synaptic conversion of chloride-dependent synapses in spinal nociceptive circuits: roles in neuropathic pain. |
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| Journal |
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| Reference |
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| Authors |
Higley MJ |
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| Title |
Localized GABAergic inhibition of dendritic Ca(2+) signalling. |
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| Journal |
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| Reference |
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| Authors |
Govindpani K, Calvo-Flores Guzman B, Vinnakota C, Waldvogel HJ, Faull RL, Kwakowsky A |
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| Title |
Towards a Better Understanding of GABAergic Remodeling in Alzheimer's Disease. |
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| Journal |
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| LinkDB |
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