KEGG   NETWORK: N01903
Entry
N01903                      Network                                
Name
Norepinephrine-ADRA2-GNAI/O signaling pathway
Definition
Norepinephrine -> ADRA2 -> (GNAI,GNAO) -| ADCY
  Expanded
C00547 -> (150,151,152) -> ((2770,2771,2773),2775) -| (107,108,109,196883,111,112,113,114,115)
Class
nt06544 Neuroactive ligand signaling
Type
Reference
Pathway
hsa04082  Neuroactive ligand signaling
Gene
150  ADRA2A; adrenoceptor alpha 2A
151  ADRA2B; adrenoceptor alpha 2B
152  ADRA2C; adrenoceptor alpha 2C
2770  GNAI1; G protein subunit alpha i1
2771  GNAI2; G protein subunit alpha i2
2773  GNAI3; G protein subunit alpha i3
2775  GNAO1; G protein subunit alpha o1
107  ADCY1; adenylate cyclase 1
108  ADCY2; adenylate cyclase 2
109  ADCY3; adenylate cyclase 3
196883  ADCY4; adenylate cyclase 4
111  ADCY5; adenylate cyclase 5
112  ADCY6; adenylate cyclase 6
113  ADCY7; adenylate cyclase 7
114  ADCY8; adenylate cyclase 8
115  ADCY9; adenylate cyclase 9
Metabolite
C00547  L-Noradrenaline
Reference
PMID:32038164
  Authors
Ranjbar-Slamloo Y, Fazlali Z
  Title
Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions?
  Journal
Front Mol Neurosci 12:334 (2019)
DOI:10.3389/fnmol.2019.00334
Reference
PMID:35492402
  Authors
Chhatar S, Lal G
  Title
Role of adrenergic receptor signalling in neuroimmune communication.
  Journal
Curr Res Immunol 2:202-217 (2021)
DOI:10.1016/j.crimmu.2021.11.001
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