KEGG   NETWORK: N01916
Entry
N01916                      Network                                
Name
Preprohormone cleavage, POMC
Definition
POMC -- PCSK1/2/3 -> MSH,Opioids
  Expanded
5443 -- (5122,5126,5045) -> (C02758,C16136,C16137,C02017,C02210,C11684)
Class
nt06544 Neuroactive ligand signaling
Type
Reference
Gene
5443  POMC; proopiomelanocortin
5122  PCSK1; proprotein convertase subtilisin/kexin type 1
5126  PCSK2; proprotein convertase subtilisin/kexin type 2
5045  FURIN; furin, paired basic amino acid cleaving enzyme
Metabolite
C02758  alpha-Melanotropin
C16136  beta-Melanotropin
C16137  gamma-Melanotropin
C02017  Corticotropin
C02210  beta-Endorphin
C11684  MET-enkephalin
Reference
PMID:26880796
  Authors
Cawley NX, Li Z, Loh YP
  Title
60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides.
  Journal
J Mol Endocrinol 56:T77-97 (2016)
DOI:10.1530/JME-15-0323
Reference
PMID:39390585
  Authors
Rullo L, Morosini C, Lacorte A, Cristani M, Coluzzi F, Candeletti S, Romualdi P
  Title
Opioid system and related ligands: from the past to future perspectives.
  Journal
J Anesth Analg Crit Care 4:70 (2024)
DOI:10.1186/s44158-024-00201-2
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