KEGG   Homo sapiens (human): 5443
Entry
5443              CDS       T01001                                 
Symbol
POMC, ACTH, CLIP, LPH, MSH, NPP, OBAIRH, POC
Name
(RefSeq) proopiomelanocortin
  KO
K05228  proopiomelanocortin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04920  Adipocytokine signaling pathway
hsa04925  Aldosterone synthesis and secretion
hsa04927  Cortisol synthesis and secretion
hsa04934  Cushing syndrome
Network
nt06310  CRH-ACTH-cortisol signaling
nt06360  Cushing syndrome
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00318  EGFR-ERK-ACTH signaling pathway
N00319  Mutation-activated USP8 to EGFR-ERK-ACTH signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
Disease
H02106  Genetic obesity
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    5443 (POMC)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5443 (POMC)
 09150 Organismal Systems
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    5443 (POMC)
   04915 Estrogen signaling pathway
    5443 (POMC)
   04916 Melanogenesis
    5443 (POMC)
   04925 Aldosterone synthesis and secretion
    5443 (POMC)
   04927 Cortisol synthesis and secretion
    5443 (POMC)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    5443 (POMC)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    5443 (POMC)
Cytokines and neuropeptides [BR:hsa04052]
 Neuropeptides
  Neuropeptides (GPCR binding)
   5443 (POMC)
SSDB
Motif
Pfam: ACTH_domain NPP Op_neuropeptide
Other DBs
NCBI-GeneID: 5443
NCBI-ProteinID: NP_000930
OMIM: 176830
HGNC: 9201
Ensembl: ENSG00000115138
CPD: C16019 C16020 C02758 C02017 C02210 C16134 C16136 C16137
UniProt: P01189
Structure
LinkDB
Position
2:complement(25160860..25168580)
AA seq 267 aa
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG
PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL
TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF
MTSEKSQTPLVTLFKNAIIKNAYKKGE
NT seq 804 nt   +upstreamnt  +downstreamnt
atgccgagatcgtgctgcagccgctcgggggccctgttgctggccttgctgcttcaggcc
tccatggaagtgcgtggctggtgcctggagagcagccagtgtcaggacctcaccacggaa
agcaacctgctggagtgcatccgggcctgcaagcccgacctctcggccgagactcccatg
ttcccgggaaatggcgacgagcagcctctgaccgagaacccccggaagtacgtcatgggc
cacttccgctgggaccgattcggccgccgcaacagcagcagcagcggcagcagcggcgca
gggcagaagcgcgaggacgtctcagcgggcgaagactgcggcccgctgcctgagggcggc
cccgagccccgcagcgatggtgccaagccgggcccgcgcgagggcaagcgctcctactcc
atggagcacttccgctggggcaagccggtgggcaagaagcggcgcccagtgaaggtgtac
cctaacggcgccgaggacgagtcggccgaggccttccccctggagttcaagagggagctg
actggccagcgactccgggagggagatggccccgacggccctgccgatgacggcgcaggg
gcccaggccgacctggagcacagcctgctggtggcggccgagaagaaggacgagggcccc
tacaggatggagcacttccgctggggcagcccgcccaaggacaagcgctacggcggtttc
atgacctccgagaagagccagacgcccctggtgacgctgttcaaaaacgccatcatcaag
aacgcctacaagaagggcgagtga

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