Homo sapiens (human): 5126
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Entry
5126 CDS
T01001
Symbol
PCSK2, NEC_2, NEC-2, NEC2, PC2, SPC2
Name
(RefSeq) proprotein convertase subtilisin/kexin type 2
KO
K01360
proprotein convertase subtilisin/kexin type 2 [EC:
3.4.21.94
]
Organism
hsa
Homo sapiens (human)
Network
nt06544
Neuroactive ligand signaling
Element
N01916
Preprohormone cleavage, POMC
N01917
Preprohormone cleavage, PDYN
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09180 Brite Hierarchies
09181 Protein families: metabolism
01002 Peptidases and inhibitors [BR:
hsa01002
]
5126 (PCSK2)
09182 Protein families: genetic information processing
03110 Chaperones and folding catalysts [BR:
hsa03110
]
5126 (PCSK2)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.4 Acting on peptide bonds (peptidases)
3.4.21 Serine endopeptidases
3.4.21.94 proprotein convertase 2
5126 (PCSK2)
Peptidases and inhibitors [BR:
hsa01002
]
Serine peptidases
Family S8: subtilisin family
5126 (PCSK2)
Chaperones and folding catalysts [BR:
hsa03110
]
Intramolecular chaperones
Subtilisin family
5126 (PCSK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Peptidase_S8
P_proprotein
S8_pro-domain
Peptidase_S8_N
Motif
Other DBs
NCBI-GeneID:
5126
NCBI-ProteinID:
NP_002585
OMIM:
162151
HGNC:
8744
Ensembl:
ENSG00000125851
UniProt:
P16519
LinkDB
All DBs
Position
20:17226107..17484578
Genome browser
AA seq
638 aa
AA seq
DB search
MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKL
PFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDIN
MNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASN
YNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRM
LDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGK
GSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK
RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRN
QLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIP
STGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRP
RDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYI
DQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN
NT seq
1917 nt
NT seq
+upstream
nt +downstream
nt
atgaagggtggttgtgtctcccagtggaaggcggccgccgggttcctcttctgtgtcatg
gtttttgcatctgctgagcgaccggtcttcacgaatcattttcttgtggagttgcataaa
gggggagaggacaaagctcgccaagttgcagcagaacacggctttggagtccgaaagctt
ccctttgctgaaggtctgtaccacttttatcacaatggccttgcaaaggccaagagaaga
cgcagcctacaccacaagcagcagctggagagagaccccagggtaaagatggctttgcag
caggaaggatttgaccgaaaaaagcgaggttacagagacatcaatgagatcgacatcaac
atgaacgatcctctttttacaaagcagtggtatctgatcaatactgggcaagctgatggc
actcctggccttgatttgaatgtggctgaagcctgggagctgggatacacagggaaaggt
gttaccattggaattatggatgatgggattgactatctccacccggacctggcctccaac
tataatgccgaagcaagttacgacttcagcagcaacgacccctatccttaccctcggtac
acagatgactggtttaacagccacgggacccgatgtgcaggagaagtttctgctgccgcc
aacaacaatatctgtggagttggagtagcatacaactccaaggttgcaggcatccggatg
ctggaccagccattcatgacagacatcatcgaggcctcctccatcagtcatatgccacag
ctgattgacatctacagcgccagctggggccccacagacaacggcaagacagtggatggg
ccccgggagctcacgctgcaggccatggccgatggcgtgaacaagggccgcggcggcaaa
ggcagcatctacgtgtgggcctccggggacggcggcagctatgacgactgcaactgcgac
ggctacgcctccagcatgtggaccatctccatcaactcagccatcaacgacggcaggact
gccctgtacgacgagagctgctcttccaccttggcttccaccttcagcaacgggaggaaa
aggaaccccgaggccggtgtggcaaccacagatttgtacggcaactgcactctgaggcat
tctgggacatctgcagctgcccccgaggcagctggtgtgtttgcactggctctggaggct
aacctgggtctgacctggcgggacatgcagcatctgactgtgctcacctccaaacggaac
cagcttcacgacgaggtccatcagtggcggcgcaatggggtcggcctggaatttaatcac
ctctttggctacggggtccttgatgcaggtgccatggtgaaaatggctaaagactggaaa
accgtgcctgagagattccactgtgtgggaggctccgtgcaggaccctgagaaaatacca
tccactggcaagttggtgctgacactcacaaccgacgcctgtgaggggaaggaaaatttt
gtccgctacctggagcatgtccaggctgtcatcacggtcaacgcaaccagaagaggagac
ctgaacatcaacatgacttcccctatgggcaccaagtccattttgctgagccggcgtcca
agggatgacgactccaaggtgggctttgacaagtggcctttcatgaccactcacacgtgg
ggggaagacgcccgaggcacctggaccctggagctgggatttgtcggcagcgccccgcag
aagggggtgctgaaggagtggaccctgatgctgcatggcactcagagtgccccgtacatc
gaccaggtggtgcgggattaccagtccaagttggccatgtccaagaaagaggagctggag
gaagagctggacgaagccgtggagagaagcctgaaaagcatccttaacaagaactag
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