KEGG   NETWORK: N01917
Entry
N01917                      Network                                
Name
Preprohormone cleavage, PDYN
Definition
PDYN -- PCSK1/2/3 -> Opioids
  Expanded
5173 -- (5122,5126,5045) -> (C16039,C16040,C01574,C16135,C16041)
Class
nt06544 Neuroactive ligand signaling
Type
Reference
Gene
5173  PDYN; prodynorphin
5122  PCSK1; proprotein convertase subtilisin/kexin type 1
5126  PCSK2; proprotein convertase subtilisin/kexin type 2
5045  FURIN; furin, paired basic amino acid cleaving enzyme
Metabolite
C16039  alpha-Neoendorphin
C16040  beta-Neoendorphin
C01574  Dynorphin
C16135  Dynorphin B
C16041  Leu-enkephalin
Reference
PMID:26880796
  Authors
Cawley NX, Li Z, Loh YP
  Title
60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides.
  Journal
J Mol Endocrinol 56:T77-97 (2016)
DOI:10.1530/JME-15-0323
Reference
PMID:39390585
  Authors
Rullo L, Morosini C, Lacorte A, Cristani M, Coluzzi F, Candeletti S, Romualdi P
  Title
Opioid system and related ligands: from the past to future perspectives.
  Journal
J Anesth Analg Crit Care 4:70 (2024)
DOI:10.1186/s44158-024-00201-2
LinkDB

DBGET integrated database retrieval system