KEGG   Homo sapiens (human): 5173
Entry
5173              CDS       T01001                                 
Symbol
PDYN, ADCA, PENKB, SCA23
Name
(RefSeq) prodynorphin
  KO
K15840  proenkephalin B (prodynorphin)
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04081  Hormone signaling
hsa04082  Neuroactive ligand signaling
hsa05017  Spinocerebellar ataxia
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
Network
nt06462  Spinocerebellar ataxia
nt06466  Pathways of neurodegeneration
nt06544  Neuroactive ligand signaling
  Element
N00971  Mutation-caused aberrant PDYN to transport of calcium
N01917  Preprohormone cleavage, PDYN
Disease
H00063  Spinocerebellar ataxia (SCA)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    5173 (PDYN)
   04082 Neuroactive ligand signaling
    5173 (PDYN)
   04081 Hormone signaling
    5173 (PDYN)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    5173 (PDYN)
   05022 Pathways of neurodegeneration - multiple diseases
    5173 (PDYN)
  09165 Substance dependence
   05030 Cocaine addiction
    5173 (PDYN)
   05031 Amphetamine addiction
    5173 (PDYN)
   05034 Alcoholism
    5173 (PDYN)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    5173 (PDYN)
   04052 Cytokines and neuropeptides [BR:hsa04052]
    5173 (PDYN)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   5173 (PDYN)
Cytokines and neuropeptides [BR:hsa04052]
 Neuropeptides
  GPCR binding
   5173 (PDYN)
SSDB
Motif
Pfam: Opiods_neuropep
Other DBs
NCBI-GeneID: 5173
NCBI-ProteinID: NP_001177821
OMIM: 131340
HGNC: 8820
Ensembl: ENSG00000101327
CPD: C16039 C16040 C16041 C16037 C01574 C16135
UniProt: P01213
Structure
LinkDB
Position
20:complement(1978756..1994285)
AA seq 254 aa
MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWE
RCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKEN
TLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLR
KYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRS
QEDPNAYSGELFDA
NT seq 765 nt   +upstreamnt  +downstreamnt
atggcctggcaggggctggtcctggctgcctgcctcctcatgttcccctccaccacagcg
gactgcctgtcgcggtgctccttgtgtgctgtaaagacccaggatggtcccaaacctatc
aatcccctgatttgctccctgcaatgccaggctgccctgctgccctctgaggaatgggag
agatgccagagctttctgtcttttttcaccccctccacccttgggctcaatgacaaggag
gacttggggagcaagtcggttggggaagggccctacagtgagctggccaagctctctggg
tcattcctgaaggagctggagaaaagcaagtttctcccaagtatctcaacaaaggagaac
actctgagcaagagcctggaggagaagctcaggggtctctctgacgggtttagggaggga
gcagagtctgagctgatgagggatgcccagctgaacgatggtgccatggagactggcaca
ctctatctcgctgaggaggaccccaaggagcaggtcaaacgctatgggggctttttgcgc
aaataccccaagaggagctcagaggtggctggggagggggacggggatagcatgggccat
gaggacctgtacaaacgctatgggggcttcttgcggcgcattcgtcccaagctcaagtgg
gacaaccagaagcgctatggcggttttctccggcgccagttcaaggtggtgactcggtct
caggaagatccgaatgcttactctggagagctttttgatgcataa

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