 | | NETWORK: N01921 | |
| Entry |
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| Name |
Integrin alpha4beta1 signaling
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| Definition |
(VCAM1,ICAM4,MADCAM1,FN1,OPN,THBS) -> ITGA4+ITGB1 -> (Adaptor,FAK,Src) |
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| Expanded |
(7412,3386,8174,2335,6696,(7057,7058,7059,7060,1311)) -> 3676+3688 -> (((2316,2317),(7094,83660),(81,87),5829,7414,(55612,10979,83706),(55742,29780,64098),(3987,55679)),5747,6714) |
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| Class |
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| Type |
Reference
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| Pathway |
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| Gene |
| 7412 | VCAM1; vascular cell adhesion molecule 1 |
| 3386 | ICAM4; intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) |
| 8174 | MADCAM1; mucosal vascular addressin cell adhesion molecule 1 |
| 6696 | SPP1; secreted phosphoprotein 1 |
| 7057 | THBS1; thrombospondin 1 |
| 7058 | THBS2; thrombospondin 2 |
| 7059 | THBS3; thrombospondin 3 |
| 7060 | THBS4; thrombospondin 4 |
| 1311 | COMP; cartilage oligomeric matrix protein |
| 3676 | ITGA4; integrin subunit alpha 4 |
| 3688 | ITGB1; integrin subunit beta 1 |
| 81 | ACTN4; actinin alpha 4 |
| 87 | ACTN1; actinin alpha 1 |
| 55612 | FERMT1; FERM domain containing kindlin 1 |
| 10979 | FERMT2; FERM domain containing kindlin 2 |
| 83706 | FERMT3; FERM domain containing kindlin 3 |
| 55742 | PARVA; parvin alpha |
| 64098 | PARVG; parvin gamma |
| 3987 | LIMS1; LIM zinc finger domain containing 1 |
| 55679 | LIMS2; LIM zinc finger domain containing 2 |
| 5747 | PTK2; protein tyrosine kinase 2 |
| 6714 | SRC; SRC proto-oncogene, non-receptor tyrosine kinase |
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| Reference |
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| Authors |
Goodman SL, Picard M |
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| Title |
Integrins as therapeutic targets. |
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| Journal |
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| Reference |
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| Authors |
Takada Y, Ye X, Simon S |
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| Title |
The integrins. |
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| Journal |
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| Reference |
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| Authors |
Pang X, He X, Qiu Z, Zhang H, Xie R, Liu Z, Gu Y, Zhao N, Xiang Q, Cui Y |
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| Title |
Targeting integrin pathways: mechanisms and advances in therapy. |
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| Journal |
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| LinkDB |
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