KEGG   NETWORK: N01963
Entry
N01963                      Network                                
Name
Sm core assembly and 3 end processing of pre U1 snRNA
Definition
(preU1snRNA+SNRNP70) == SMN == SmCore -- TOE1 -> preU1snRNP
  Expanded
(26871+6625) == (6606+6607+8487+11218+50628+25929+54960+79833+79760+11171) == (6628+6634+6632+6633+6635+6636+6637) -- 114034 -> (26871+6625)+(6628+6634+6632+6633+6635+6636+6637)
Class
nt06547 Spliceosome
Type
Reference
Pathway
hsa03040  Spliceosome
Gene
26871  RNU1-1; RNA, U1 small nuclear 1
6625  SNRNP70; small nuclear ribonucleoprotein U1 subunit 70
6606  SMN1; survival of motor neuron 1, telomeric
6607  SMN2; survival of motor neuron 2, centromeric
8487  GEMIN2; gem nuclear organelle associated protein 2
11218  DDX20; DEAD-box helicase 20
50628  GEMIN4; gem nuclear organelle associated protein 4
25929  GEMIN5; gem nuclear organelle associated protein 5
54960  GEMIN8; gem nuclear organelle associated protein 8
79833  GEMIN6; gem nuclear organelle associated protein 6
79760  GEMIN7; gem nuclear organelle associated protein 7
11171  STRAP; serine/threonine kinase receptor associated protein
6628  SNRPB; small nuclear ribonucleoprotein polypeptides B and B1
6634  SNRPD3; small nuclear ribonucleoprotein D3 polypeptide
6632  SNRPD1; small nuclear ribonucleoprotein D1 polypeptide
6633  SNRPD2; small nuclear ribonucleoprotein D2 polypeptide
6635  SNRPE; small nuclear ribonucleoprotein polypeptide E
6636  SNRPF; small nuclear ribonucleoprotein polypeptide F
6637  SNRPG; small nuclear ribonucleoprotein polypeptide G
114034  TOE1; target of EGR1, exonuclease
Reference
PMID:38459794
  Authors
Campagne S
  Title
U1 snRNP Biogenesis Defects in Neurodegenerative Diseases.
  Journal
Chembiochem 25:e202300864 (2024)
DOI:10.1002/cbic.202300864
Reference
PMID:37645788
  Authors
Ma T, Xiong ES, Lardelli RM, Lykke-Andersen J
  Title
The 3' exonuclease TOE1 selectively processes snRNAs through recognition of Sm complex assembly and 5' cap trimethylation.
  Journal
bioRxiv 2023.08.15.553431 (2023)
DOI:10.1101/2023.08.15.553431
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