KEGG   NETWORK: N01981
Entry
N01981                      Network                                
Name
Integrin alpha8beta1 signaling
Definition
((NPNT+FRAS1+FREM),FN1,VTN,TN,LAP) -> ITGA8+ITGB1 -> (Adaptor,FAK,Src)
  Expanded
((255743+80144+(158326,341640)),2335,7448,(3371,63923,7143,7148),7040) -> 8516+3688 -> (((2316,2317),(7094,83660),(81,87),5829,7414,(55612,10979,83706),(55742,29780,64098),(3987,55679)),5747,6714)
Class
nt06548 Integrin signaling
Type
Reference
Pathway
hsa04518 Integrin signaling   
Gene
255743  NPNT; nephronectin
80144  FRAS1; Fraser extracellular matrix complex subunit 1
158326  FREM1; FRAS1 related extracellular matrix 1
341640  FREM2; FRAS1 related extracellular matrix 2
2335  FN1; fibronectin 1
7448  VTN; vitronectin
3371  TNC; tenascin C
63923  TNN; tenascin N
7143  TNR; tenascin R
7148  TNXB; tenascin XB
7040  TGFB1; transforming growth factor beta 1
8516  ITGA8; integrin subunit alpha 8
3688  ITGB1; integrin subunit beta 1
2316  FLNA; filamin A
2317  FLNB; filamin B
7094  TLN1; talin 1
83660  TLN2; talin 2
81  ACTN4; actinin alpha 4
87  ACTN1; actinin alpha 1
5829  PXN; paxillin
7414  VCL; vinculin
55612  FERMT1; FERM domain containing kindlin 1
10979  FERMT2; FERM domain containing kindlin 2
83706  FERMT3; FERM domain containing kindlin 3
55742  PARVA; parvin alpha
29780  PARVB; parvin beta
64098  PARVG; parvin gamma
3987  LIMS1; LIM zinc finger domain containing 1
55679  LIMS2; LIM zinc finger domain containing 2
5747  PTK2; protein tyrosine kinase 2
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase
Reference
PMID:22633092
  Authors
Goodman SL, Picard M
  Title
Integrins as therapeutic targets.
  Journal
Trends Pharmacol Sci 33:405-12 (2012)
DOI:10.1016/j.tips.2012.04.002
Reference
PMID:17543136
  Authors
Takada Y, Ye X, Simon S
  Title
The integrins.
  Journal
Genome Biol 8:215 (2007)
DOI:10.1186/gb-2007-8-5-215
Reference
PMID:36588107
  Authors
Pang X, He X, Qiu Z, Zhang H, Xie R, Liu Z, Gu Y, Zhao N, Xiang Q, Cui Y
  Title
Targeting integrin pathways: mechanisms and advances in therapy.
  Journal
Signal Transduct Target Ther 8:1 (2023)
DOI:10.1038/s41392-022-01259-6
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