KEGG   NETWORK: N02010
Entry
N02010                      Network                                
Name
Wnt signaling pathway, PCP pathway
Definition
WNT5/11 -> (FZD3/6+CELSR) -> (DVL+ANKRD6) -> ((DAAM1,RHOA,ROCK),RAC)
  Expanded
(7474,81029,7481) -> ((7976,8323)+(9620,1952,1951)) -> ((1855,1856,1857)+22881) -> ((23002,387,(6093,9475)),(5879,5880,5881))
Class
nt06505 WNT signaling
nt06549 Cadherin signaling
Type
Reference
Pathway
hsa04310 Wnt signaling pathway   
hsa04519 Cadherin signaling   
Gene
7474  WNT5A; Wnt family member 5A
81029  WNT5B; protein Wnt-5b precursor
7481  WNT11; protein Wnt-11 precursor
7976  FZD3; frizzled class receptor 3
8323  FZD6; frizzled class receptor 6
9620  CELSR1; cadherin EGF LAG seven-pass G-type receptor 1
1952  CELSR2; cadherin EGF LAG seven-pass G-type receptor 2
1951  CELSR3; cadherin EGF LAG seven-pass G-type receptor 3
1855  DVL1; dishevelled segment polarity protein 1
1856  DVL2; dishevelled segment polarity protein 2
1857  DVL3; dishevelled segment polarity protein 3
22881  ANKRD6; ankyrin repeat domain 6
23002  DAAM1; dishevelled associated activator of morphogenesis 1
387  RHOA; ras homolog family member A
6093  ROCK1; Rho associated coiled-coil containing protein kinase 1
9475  ROCK2; Rho associated coiled-coil containing protein kinase 2
5879  RAC1; Rac family small GTPase 1
5880  RAC2; Rac family small GTPase 2
5881  RAC3; Rac family small GTPase 3
Reference
PMID:39768206
  Authors
Shi DL
  Title
Breaking Left-Right Symmetry by the Interplay of Planar Cell Polarity, Calcium Signaling and Cilia.
  Journal
Cells 13:cells13242116 (2024)
DOI:10.3390/cells13242116
Reference
PMID:40295529
  Authors
Bandekar SJ, Garbett K, Kordon SP, Dintzner EE, Li J, Shearer T, Sando RC, Arac D
  Title
Structural basis for regulation of CELSR1 by a compact module in its extracellular region.
  Journal
Nat Commun 16:3972 (2025)
DOI:10.1038/s41467-025-59319-8
Reference
PMID:30213499
  Authors
Chae WJ, Bothwell ALM
  Title
Canonical and Non-Canonical Wnt Signaling in Immune Cells.
  Journal
Trends Immunol 39:830-847 (2018)
DOI:10.1016/j.it.2018.08.006
Reference
PMID:35297539
  Authors
Hayat R, Manzoor M, Hussain A
  Title
Wnt signaling pathway: A comprehensive review.
  Journal
Cell Biol Int 46:863-877 (2022)
DOI:10.1002/cbin.11797
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