| Entry |
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| Name |
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
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| Definition |
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
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| Equation |
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| Comment |
2-oxoglutarate dehydrogenase complex: pyruvate dehydrogenase (see R01699), subsequently R03270
TPP-dependent enzymatic reaction (see R00006), subsequently R03050
TPP-dependent enzymatic reaction (see R00226), subsequently R04672
TPP-dependent enzymatic reaction (see R00224), subsequently R00755
TPP-dependent enzymatic reaction (see R08648), subsequently R04673
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| Reaction class |
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| Enzyme |
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| Pathway |
| rn00010 | Glycolysis / Gluconeogenesis |
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| Module |
| M00307 | Pyruvate oxidation, pyruvate => acetyl-CoA |
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| Brite |
Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1
R00014 Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
2. Transferase reactions
2.2 Transferring aldehyde or ketonic groups
2.2.1 Transketolases and transaldolases
2.2.1.6
R00014 Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
4. Lyase reactions
4.1 Carbon-carbon lyases
4.1.1 Carboxy-lyases
4.1.1.1
R00014 Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
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| Orthology |
| K00161 | pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1] |
| K00162 | pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1] |
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| LinkDB |
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