KEGG   REACTION: R01074
Entry
R01074                      Reaction                               
Name
biotin:CoA ligase (AMP-forming);
biotin:apo-[carboxylase] ligase (AMP-forming);
ATP:biotin adenylyltransferase
Definition
ATP + Biotin <=> Diphosphate + Biotinyl-5'-AMP
Equation
C00002 + C00120 <=> C00013 + C05921
Comment
the first step of two-step reaction (R01075, R04562, R04563, R04582 or R04604)
subsequently R05145 or R03762
Reaction class
RC00043  C00120_C05921
Enzyme
6.2.1.11        6.3.4.9         6.3.4.10        6.3.4.11        
6.3.4.15
Pathway
rn00780  Biotin metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.11
     R01074  ATP + Biotin <=> Diphosphate + Biotinyl-5'-AMP
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.9
     R01074  ATP + Biotin <=> Diphosphate + Biotinyl-5'-AMP
    6.3.4.10
     R01074  ATP + Biotin <=> Diphosphate + Biotinyl-5'-AMP
    6.3.4.11
     R01074  ATP + Biotin <=> Diphosphate + Biotinyl-5'-AMP
    6.3.4.15
     R01074  ATP + Biotin <=> Diphosphate + Biotinyl-5'-AMP
Orthology
K01942  biotin---protein ligase [EC:6.3.4.9 6.3.4.10 6.3.4.11 6.3.4.15]
K01947  biotin---[acetyl-CoA-carboxylase] ligase / type III pantothenate kinase [EC:6.3.4.15 2.7.1.33]
K03524  BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]
Other DBs
RHEA: 31118
LinkDB

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