KEGG   REACTION: R01210
Entry
R01210                      Reaction                               
Name
3-methyl-2-oxobutanoate:NAD+ oxidoreductase (CoA-mehtylpropanoylating)
Definition
3-Methyl-2-oxobutanoic acid + CoA + NAD+ <=> 2-Methylpropanoyl-CoA + CO2 + NADH + H+
Equation
C00141 + C00010 + C00003 <=> C00630 + C00011 + C00004 + C00080
Comment
multienzyme system: ec 1.2.4.4, ec 2.3.1.168 and ec 1.8.1.4
multi-step reaction (see R01701+R02662+R07618)
Reaction class
RC00001  C00003_C00004
RC00004  C00010_C00630
RC02856  C00141_C00630
Enzyme
1.2.1.25
Pathway
rn01210  2-Oxocarboxylic acid metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.25
     R01210  3-Methyl-2-oxobutanoic acid + CoA + NAD+ <=> 2-Methylpropanoyl-CoA + CO2 + NADH + H+
Orthology
K00166  2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:1.2.4.4]
K00167  2-oxoisovalerate dehydrogenase E1 component subunit beta [EC:1.2.4.4]
K00382  dihydrolipoyl dehydrogenase [EC:1.8.1.4]
K09699  2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase) [EC:2.3.1.168]
K11381  2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]
Other DBs
RHEA: 14000
LinkDB

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