KEGG   REACTION: R01221
Entry
R01221                      Reaction                               
Name
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding);
glycine cleavage system
Definition
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
Equation
C00037 + C00101 + C00003 <=> C00143 + C00014 + C00011 + C00004 + C00080
Comment
multienzyme system
multi-step reaction (see R03425+R04125+R03815)
Reaction class
RC00001  C00003_C00004
RC00022  C00101_C00143
RC02834  C00014_C00037
Enzyme
1.4.1.27
Pathway
rn00630  Glyoxylate and dicarboxylate metabolism
rn00670  One carbon pool by folate
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01200  Carbon metabolism
Module
M00532  Photorespiration
M00621  Glycine cleavage system
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.27
     R01221  Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
Orthology
K00281  glycine cleavage system P protein (glycine dehydrogenase) [EC:1.4.4.2]
K00282  glycine cleavage system P protein (glycine dehydrogenase) subunit 1 [EC:1.4.4.2]
K00283  glycine cleavage system P protein (glycine dehydrogenase) subunit 2 [EC:1.4.4.2]
K00382  dihydrolipoyl dehydrogenase [EC:1.8.1.4]
K00605  glycine cleavage system T protein (aminomethyltransferase) [EC:2.1.2.10]
K02437  glycine cleavage system H protein
Other DBs
RHEA: 27761
LinkDB

KEGG   REACTION: R03425
Entry
R03425                      Reaction                               
Name
glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)
Definition
Glycine + Lipoylprotein <=> [Protein]-S8-aminomethyldihydrolipoyllysine + CO2
Equation
C00037 + C02051 <=> C01242 + C00011
Comment
a part step of glycine cleavage system (see R01221, R03425+R04125+R03815)
Reaction class
RC00929  C01242_C02051
RC02880  C00037_C01242
Enzyme
1.4.4.2
Pathway
rn00260  Glycine, serine and threonine metabolism
rn00785  Lipoic acid metabolism
rn01100  Metabolic pathways
rn01200  Carbon metabolism
Module
M00621  Glycine cleavage system
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.4  Acting on the CH-NH2 group of donors
   1.4.4  With a disulfide as acceptor
    1.4.4.2
     R03425  Glycine + Lipoylprotein <=> [Protein]-S8-aminomethyldihydrolipoyllysine + CO2
Orthology
K00281  glycine cleavage system P protein (glycine dehydrogenase) [EC:1.4.4.2]
K00282  glycine cleavage system P protein (glycine dehydrogenase) subunit 1 [EC:1.4.4.2]
K00283  glycine cleavage system P protein (glycine dehydrogenase) subunit 2 [EC:1.4.4.2]
Other DBs
RHEA: 24307
LinkDB

KEGG   REACTION: R04125
Entry
R04125                      Reaction                               
Name
[protein]-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming)
Definition
[Protein]-S8-aminomethyldihydrolipoyllysine + Tetrahydrofolate <=> Dihydrolipoylprotein + 5,10-Methylenetetrahydrofolate + Ammonia
Equation
C01242 + C00101 <=> C02972 + C00143 + C00014
Comment
a part step of glycine cleavage system (see R01221, R03425+R04125+R03815)
Reaction class
RC00022  C00101_C00143
RC00069  C01242_C02972
Enzyme
2.1.2.10
Pathway
rn00260  Glycine, serine and threonine metabolism
rn00670  One carbon pool by folate
rn00785  Lipoic acid metabolism
rn01100  Metabolic pathways
rn01200  Carbon metabolism
Module
M00621  Glycine cleavage system
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.2  Hydroxymethyl-, formyl- and related transferases
    2.1.2.10
     R04125  [Protein]-S8-aminomethyldihydrolipoyllysine + Tetrahydrofolate <=> Dihydrolipoylprotein + 5,10-Methylenetetrahydrofolate + Ammonia
Orthology
K00605  glycine cleavage system T protein (aminomethyltransferase) [EC:2.1.2.10]
Other DBs
RHEA: 16948
LinkDB

KEGG   REACTION: R03815
Entry
R03815                      Reaction                               
Name
dihydrolipoylprotein:NAD+ oxidoreductase
Definition
Dihydrolipoylprotein + NAD+ <=> Lipoylprotein + NADH + H+
Equation
C02972 + C00003 <=> C02051 + C00004 + C00080
Comment
a part step of glycine cleavage system (see R01221, R03425+R04125+R03815)
Reaction class
RC00001  C00003_C00004
RC00583  C02051_C02972
Enzyme
1.8.1.4
Pathway
rn00260  Glycine, serine and threonine metabolism
rn00785  Lipoic acid metabolism
rn01100  Metabolic pathways
rn01200  Carbon metabolism
Module
M00621  Glycine cleavage system
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.8  Acting on a sulfur group of donors
   1.8.1  With NAD+ or NADP+ as acceptor
    1.8.1.4
     R03815  Dihydrolipoylprotein + NAD+ <=> Lipoylprotein + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.8.1.4
   R08550  [Protein]-N6-[(R)-dihydrolipoyl]-L-lysine <=> Protein N6-(lipoyl)lysine
    R03815  Dihydrolipoylprotein <=> Lipoylprotein
Orthology
K00382  dihydrolipoyl dehydrogenase [EC:1.8.1.4]
Other DBs
RHEA: 15048
LinkDB

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