KEGG   REACTION: R02216
Entry
R02216                      Reaction                               
Name
pregnenolone:NAD+ 3-oxidoreductase
Definition
Pregnenolone + NAD+ <=> Progesterone + NADH + H+
Equation
C01953 + C00003 <=> C00410 + C00004 + C00080
Comment
3beta-hydroxysteroid dehydrogenase/ Delta5-Delta4-isomerase
two-step reaction
Reaction class
RC00001  C00003_C00004
RC00146  C00410_C01953
Enzyme
1.1.1.145       5.3.3.1
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145
     R02216  Pregnenolone + NAD+ <=> Progesterone + NADH + H+
 5. Isomerase reactions
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1
     R02216  Pregnenolone + NAD+ <=> Progesterone + NADH + H+
Orthology
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
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