KEGG   REACTION: R02443
Entry
R02443                      Reaction                               
Name
naringenin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Definition
Naringenin + 2 [Reduced NADPH---hemoprotein reductase] + 2 Oxygen <=> Pentahydroxyflavanone + 2 [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Equation
C00509 + 2 C03024 + 2 C00007 <=> C05911 + 2 C03161 + 2 C00001
Comment
flavonoid 3',5'-hydroxylase
flavonoid 3',5'-monooxygenase
two-step reaction (see R02442+R04902)
Enzyme
1.14.14.81
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.81
     R02443  Naringenin + 2 [Reduced NADPH---hemoprotein reductase] + 2 Oxygen <=> Pentahydroxyflavanone + 2 [Oxidized NADPH---hemoprotein reductase] + 2 H2O
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.14.14.81
   R10069  Flavanone <=> 3',5'-Dihydroxyflavanone
    R02443  Naringenin <=> Pentahydroxyflavanone
LinkDB

KEGG   REACTION: R02442
Entry
R02442                      Reaction                               
Name
naringenin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (3'-hydroxylating)
Definition
Naringenin + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Eriodictyol + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C00509 + C03024 + C00007 <=> C05631 + C03161 + C00001
Comment
flavonoid 3'-hydroxylase
flavonoid 3'-monooxygenase
first step of two-step reaction (see R02443, R02442+R04902)
Reaction class
RC00046  C00509_C05631
Enzyme
1.14.14.81      1.14.14.82
Pathway
rn00941  Flavonoid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.81
     R02442  Naringenin + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Eriodictyol + [Oxidized NADPH---hemoprotein reductase] + H2O
    1.14.14.82
     R02442  Naringenin + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Eriodictyol + [Oxidized NADPH---hemoprotein reductase] + H2O
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.14.14.81
   R07369  Flavanone <=> 3'-Hydroxyflavanone
    R02442  Naringenin <=> Eriodictyol
  1.14.14.82
   R03615  Flavonoid <=> 3'-Hydroxyflavonoid
    R02442  Naringenin <=> Eriodictyol
Orthology
K05280  flavonoid 3'-monooxygenase [EC:1.14.14.82]
K13083  flavonoid 3',5'-hydroxylase [EC:1.14.14.81]
Other DBs
RHEA: 61099
LinkDB

KEGG   REACTION: R04902
Entry
R04902                      Reaction                               
Name
eriodictyol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Definition
Eriodictyol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Pentahydroxyflavanone + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C05631 + C03024 + C00007 <=> C05911 + C03161 + C00001
Comment
flavonoid 3',5'-hydroxylase
flavonoid 3',5'-monooxygenase
second step of two-step reaction (see R02443, R02442+R04902)
Reaction class
RC00046  C05631_C05911
Enzyme
1.14.14.81
Pathway
rn00941  Flavonoid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.81
     R04902  Eriodictyol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Pentahydroxyflavanone + [Oxidized NADPH---hemoprotein reductase] + H2O
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.14.14.81
   R07370  3'-Hydroxyflavanone <=> 3',5'-Dihydroxyflavanone
    R04902  Eriodictyol <=> Pentahydroxyflavanone
Orthology
K13083  flavonoid 3',5'-hydroxylase [EC:1.14.14.81]
Other DBs
RHEA: 61103
LinkDB

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