KEGG   REACTION: R02722
Entry
R02722                      Reaction                               
Name
L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming]
Definition
L-Serine + Indoleglycerol phosphate <=> L-Tryptophan + D-Glyceraldehyde 3-phosphate + H2O
Equation
C00065 + C03506 <=> C00078 + C00118 + C00001
Comment
multi-step reaction (see R02340+R00674)
Reaction class
RC00210  C00065_C00078
RC00700  C00118_C03506
RC02868  C00078_C03506
Enzyme
4.2.1.20
Pathway
rn00260  Glycine, serine and threonine metabolism
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01230  Biosynthesis of amino acids
Module
M00023  Tryptophan biosynthesis, chorismate => tryptophan
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.20
     R02722  L-Serine + Indoleglycerol phosphate <=> L-Tryptophan + D-Glyceraldehyde 3-phosphate + H2O
Orthology
K01694  tryptophan synthase [EC:4.2.1.20]
K01695  tryptophan synthase alpha chain [EC:4.2.1.20]
K01696  tryptophan synthase beta chain [EC:4.2.1.20]
K06001  tryptophan synthase beta chain [EC:4.2.1.20]
Other DBs
RHEA: 10535
LinkDB

KEGG   REACTION: R02340
Entry
R02340                      Reaction                               
Name
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase
Definition
Indoleglycerol phosphate <=> Indole + D-Glyceraldehyde 3-phosphate
Equation
C03506 <=> C00463 + C00118
Comment
a part of multi-step reaction (ec 4.2.1.20, see R02722, R02340+R00674)
Reaction class
RC00700  C00118_C03506
RC00701  C00463_C03506
Enzyme
4.1.2.8         4.2.1.20
Pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn00402  Benzoxazinoid biosynthesis
rn00999  Biosynthesis of various plant secondary metabolites
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00952  Benzoxazinoid biosynthesis, indoleglycerol phosphate => DIMBOA-glucoside
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.8
     R02340  Indoleglycerol phosphate <=> Indole + D-Glyceraldehyde 3-phosphate
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.20
     R02340  Indoleglycerol phosphate <=> Indole + D-Glyceraldehyde 3-phosphate
Orthology
K01695  tryptophan synthase alpha chain [EC:4.2.1.20]
K01696  tryptophan synthase beta chain [EC:4.2.1.20]
K06001  tryptophan synthase beta chain [EC:4.2.1.20]
K13222  indole-3-glycerol-phosphate lyase [EC:4.1.2.8]
Other DBs
RHEA: 14084
LinkDB

KEGG   REACTION: R00674
Entry
R00674                      Reaction                               
Name
L-serine hydro-lyase (adding indole; L-tryptophan-forming)
Definition
L-Serine + Indole <=> L-Tryptophan + H2O
Equation
C00065 + C00463 <=> C00078 + C00001
Comment
multi-step reaction
intermediate (2-aminoacrylate Schiff base with PLP)
Reaction class
RC00209  C00078_C00463
RC00210  C00065_C00078
Enzyme
4.2.1.20        4.2.1.122
Pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.20
     R00674  L-Serine + Indole <=> L-Tryptophan + H2O
    4.2.1.122
     R00674  L-Serine + Indole <=> L-Tryptophan + H2O
Orthology
K01695  tryptophan synthase alpha chain [EC:4.2.1.20]
K01696  tryptophan synthase beta chain [EC:4.2.1.20]
K06001  tryptophan synthase beta chain [EC:4.2.1.20]
Other DBs
RHEA: 26437
LinkDB

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