KEGG   REACTION: R03784
Entry
R03784                      Reaction                               
Name
pregnenolone,NADPH-hemoprotein reductase:oxygen oxidoreductase (21-hydroxylating)
Definition
Pregnenolone + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 21-Hydroxypregnenolone + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
Reaction class
RC00157  C01953_C05485
Enzyme
Pathway
rn00140  Steroid hormone biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.16
     R03784  Pregnenolone + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 21-Hydroxypregnenolone + [Oxidized NADPH---hemoprotein reductase] + H2O
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.14.14.16
   R02130  Steroid <=> 21-Hydroxysteroid
    R03784  Pregnenolone <=> 21-Hydroxypregnenolone
Orthology
K00513  steroid 21-monooxygenase [EC:1.14.14.16]
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