Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
A P-450 heme-thiolate protein responsible for the conversion of progesterone and 17alpha-hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-deoxycortisol. Involved in the biosynthesis of the hormones aldosterone and cortisol. The electron donor is EC 126.96.36.199, NADPH---hemoprotein reductase.
EC 188.8.131.52 created 1961 as EC 184.108.40.206, transferred 1965 to EC 220.127.116.11, transferred 1972 to EC 18.104.22.168, modified 2013, transferred 2015 to EC 22.214.171.124