KEGG   REACTION: R04426
Entry
R04426                      Reaction                               
Name
(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase
Definition
(2R,3S)-3-Isopropylmalate + NAD+ <=> (2S)-2-Isopropyl-3-oxosuccinate + NADH + H+
Equation
C04411 + C00003 <=> C04236 + C00004 + C00080
Comment
subsequently R01652
Reaction class
RC00001  C00003_C00004
RC00084  C04236_C04411
Enzyme
1.1.1.85
Pathway
rn00290  Valine, leucine and isoleucine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01210  2-Oxocarboxylic acid metabolism
Module
M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.85
     R04426  (2R,3S)-3-Isopropylmalate + NAD+ <=> (2S)-2-Isopropyl-3-oxosuccinate + NADH + H+
Orthology
K00052  3-isopropylmalate dehydrogenase [EC:1.1.1.85]
K21360  3-isopropylmalate/methylthioalkylmalate dehydrogenase [EC:1.1.1.85 1.1.1.-]
Other DBs
RHEA: 10895
LinkDB

KEGG   REACTION: R01652
Entry
R01652                      Reaction                               
Definition
4-Methyl-2-oxopentanoate + CO2 <=> (2S)-2-Isopropyl-3-oxosuccinate
Equation
C00233 + C00011 <=> C04236
Comment
spontaneous (following EC 1.1.1.85 or R04426 reaction)
Reaction class
RC00577  C00233_C04236
Enzyme
1.1.1.85
Pathway
rn00290  Valine, leucine and isoleucine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01210  2-Oxocarboxylic acid metabolism
Module
M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.85
     R01652  4-Methyl-2-oxopentanoate + CO2 <=> (2S)-2-Isopropyl-3-oxosuccinate
Other DBs
RHEA: 25081
LinkDB

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