KEGG REACTION: R05469

REACTION: R05469

Entry

R05469                      Reaction

Name

dihydroclavaminate,2-oxoglutarate:oxygen oxidoreductase (desaturating)

Definition

Dihydroclavaminic acid + Oxygen + 2-Oxoglutarate <=> Clavaminic acid + Succinate + CO2 + H2O

Equation

C06659 + C00007 + C00026 <=> C06660 + C00042 + C00011 + C00001

Comment

see R05467, R05468

Reaction class

RC01391

C06659_C06660

Enzyme

1.14.11.21

Pathway

rn00331

Clavulanic acid biosynthesis

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

Module

M00674

Clavaminate biosynthesis, arginine + glyceraldehyde-3P => clavaminate

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.21
     R05469  Dihydroclavaminic acid + Oxygen + 2-Oxoglutarate <=> Clavaminic acid + Succinate + CO2 + H2O

Orthology

K12675

clavaminate synthase [EC:1.14.11.21]

Reference

1 [PMID:9614345]

Authors

McGowan SJ, Bycroft BW, Salmond GP.

Title

Bacterial production of carbapenems and clavams: evolution of beta-lactam antibiotic pathways.

Journal

Trends Microbiol 6:203-8 (1998)
DOI:10.1016/S0966-842X(98)01251-7

LinkDB

RCLASS: RC01391