KEGG   REACTION: R05728
Entry
R05728                      Reaction                               
Name
(E)-4-hydroxyphenylacetaldehyde oxime,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase
Definition
(E)-4-Hydroxyphenylacetaldehyde oxime + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> (S)-4-Hydroxymandelonitrile + [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Equation
Comment
three-step reaction (R11442+R04306+R02708)
Enzyme
Pathway
rn00460  Cyanoamino acid metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00369  Cyanogenic glycoside biosynthesis, tyrosine => dhurrin
Orthology
K13029  4-hydroxyphenylacetaldehyde oxime monooxygenase [EC:1.14.14.37]
Reference
1  [PMID:9484480]
  Authors
Bak S, Kahn RA, Nielsen HL, Moller BL, Halkier BA
  Title
Cloning of three A-type cytochromes P450, CYP71E1, CYP98, and CYP99 from Sorghum bicolor (L.) Moench by a PCR approach and identification by expression in Escherichia coli of CYP71E1 as a multifunctional cytochrome P450 in the biosynthesis of the cyanogenic glucoside dhurrin.
  Journal
Plant Mol Biol 36:393-405 (1998)
DOI:10.1023/A:1005915507497
Other DBs
RHEA: 18404
LinkDB

KEGG   REACTION: R11442
Entry
R11442                      Reaction                               
Definition
(E)-4-Hydroxyphenylacetaldehyde oxime <=> (Z)-4-Hydroxyphenylacetaldehyde oxime
Equation
Comment
first step of three-step reaction (see R05728, R11442+R04306+R02708)
Reaction class
RC01159  C04350_C04353
Enzyme
Orthology
K13029  4-hydroxyphenylacetaldehyde oxime monooxygenase [EC:1.14.14.37]
Reference
1  [PMID:9484480]
  Authors
Bak S, Kahn RA, Nielsen HL, Moller BL, Halkier BA
  Title
Cloning of three A-type cytochromes P450, CYP71E1, CYP98, and CYP99 from Sorghum bicolor (L.) Moench by a PCR approach and identification by expression in Escherichia coli of CYP71E1 as a multifunctional cytochrome P450 in the biosynthesis of the cyanogenic glucoside dhurrin.
  Journal
Plant Mol Biol 36:393-405 (1998)
DOI:10.1023/A:1005915507497
Other DBs
RHEA: 50727
LinkDB

KEGG   REACTION: R04306
Entry
R04306                      Reaction                               
Definition
(Z)-4-Hydroxyphenylacetaldehyde oxime <=> 4-Hydroxyphenylacetonitrile + H2O
Equation
Comment
second step of three-step reaction (see R05728, R11442+R04306+R02708)
subsequently R02708
Reaction class
RC01076  C03766_C04353
Enzyme
Orthology
K13029  4-hydroxyphenylacetaldehyde oxime monooxygenase [EC:1.14.14.37]
Reference
1  [PMID:9484480]
  Authors
Bak S, Kahn RA, Nielsen HL, Moller BL, Halkier BA
  Title
Cloning of three A-type cytochromes P450, CYP71E1, CYP98, and CYP99 from Sorghum bicolor (L.) Moench by a PCR approach and identification by expression in Escherichia coli of CYP71E1 as a multifunctional cytochrome P450 in the biosynthesis of the cyanogenic glucoside dhurrin.
  Journal
Plant Mol Biol 36:393-405 (1998)
DOI:10.1023/A:1005915507497
Other DBs
RHEA: 50731
LinkDB

KEGG   REACTION: R02708
Entry
R02708                      Reaction                               
Name
4-hydroxyphenylacetonitrile,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase
Definition
4-Hydroxyphenylacetonitrile + Oxygen + [Reduced NADPH---hemoprotein reductase] <=> (S)-4-Hydroxymandelonitrile + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
Comment
last step of three-step reaction (see R05728, R11442+R04306+R02708)
following after R04306
Reaction class
RC02540  C03742_C03766
Enzyme
Orthology
K13029  4-hydroxyphenylacetaldehyde oxime monooxygenase [EC:1.14.14.37]
Reference
1  [PMID:9484480]
  Authors
Bak S, Kahn RA, Nielsen HL, Moller BL, Halkier BA
  Title
Cloning of three A-type cytochromes P450, CYP71E1, CYP98, and CYP99 from Sorghum bicolor (L.) Moench by a PCR approach and identification by expression in Escherichia coli of CYP71E1 as a multifunctional cytochrome P450 in the biosynthesis of the cyanogenic glucoside dhurrin.
  Journal
Plant Mol Biol 36:393-405 (1998)
DOI:10.1023/A:1005915507497
Other DBs
RHEA: 50735
LinkDB

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