KEGG   REACTION: R07399
Entry
R07399                      Reaction                               
Definition
Acetyl-CoA + Pyruvate + H2O <=> (R)-2-Methylmalate + CoA
Equation
C00024 + C00022 + C00001 <=> C02612 + C00010
Reaction class
RC00004  C00010_C00024
RC01205  C00022_C02612
Enzyme
2.3.3.21
Pathway
rn00290  Valine, leucine and isoleucine biosynthesis
rn00660  C5-Branched dibasic acid metabolism
rn01100  Metabolic pathways
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00535  Isoleucine biosynthesis, pyruvate => 2-oxobutanoate
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.21
     R07399  Acetyl-CoA + Pyruvate + H2O <=> (R)-2-Methylmalate + CoA
Orthology
K09011  (R)-citramalate synthase [EC:2.3.3.21]
Other DBs
RHEA: 19048
LinkDB

KEGG   RCLASS: RC01205
Entry
RC01205                     RClass                                 
Definition
C1d-C5a:C1b-*:C1a+C6a+O1a-C1a+C6a+O5a
Reactant pair
C00022_C01011    C00022_C02612    C00022_C02614
C00022_C06033    C00022_C20746
Related class
Reaction
R00008 R00237 R00325 R07399 R10674
Enzyme
2.3.3.21        4.1.3.17        4.1.3.22        4.1.3.25        
4.1.3.46
Pathway
rn00290  Valine, leucine and isoleucine biosynthesis
rn00362  Benzoate degradation
rn00660  C5-Branched dibasic acid metabolism
rn00720  Other carbon fixation pathways
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
RModule
RM001  2-Oxocarboxylic acid chain extension by tricarboxylic acid pathway
Orthology
K08691  malyl-CoA/(S)-citramalyl-CoA lyase [EC:4.1.3.24 4.1.3.25]
K09011  (R)-citramalate synthase [EC:2.3.3.21]
K10218  4-hydroxy-4-methyl-2-oxoglutarate aldolase [EC:4.1.3.17]
K18292  (S)-citramalyl-CoA lyase [EC:4.1.3.25]
K18314  (R)-citramalyl-CoA lyase [EC:4.1.3.46]

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