KEGG   REACTION: R07971
Entry
R07971                      Reaction                               
Definition
Caffeine + NADH + H+ + Oxygen <=> Theophylline + NAD+ + Formaldehyde + H2O
Equation
C07481 + C00004 + C00080 + C00007 <=> C07130 + C00003 + C00067 + C00001
Comment
caffeine demethylase
Reaction class
RC00001  C00003_C00004
RC01797  C00067_C07481
RC01827  C07130_C07481
Enzyme
1.13.12.-
Pathway
rn00232  Caffeine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.12  With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
    1.13.12.-
     R07971  Caffeine + NADH + H+ + Oxygen <=> Theophylline + NAD+ + Formaldehyde + H2O
LinkDB

KEGG   REACTION: R07972
Entry
R07972                      Reaction                               
Definition
Caffeine + NADPH + H+ + Oxygen <=> Theophylline + NADP+ + Formaldehyde + H2O
Equation
C07481 + C00005 + C00080 + C00007 <=> C07130 + C00006 + C00067 + C00001
Comment
caffeine demethylase
Reaction class
RC00001  C00005_C00006
RC01797  C00067_C07481
RC01827  C07130_C07481
Enzyme
1.13.12.-
Pathway
rn00232  Caffeine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.12  With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
    1.13.12.-
     R07972  Caffeine + NADPH + H+ + Oxygen <=> Theophylline + NADP+ + Formaldehyde + H2O
LinkDB

KEGG   RCLASS: RC01827
Entry
RC01827                     RClass                                 
Definition
N4x-N4y:*-C1a:C8x+C8y-C8x+C8y
Reactant pair
C00385_C16353    C07130_C07481    C07480_C16357
C13747_C16358
Related class
Reaction
R07943 R07959 R07960 R07963 R07964 R07965 R07966 R07971
R07972
Enzyme
1.13.12.-       1.14.13.128     1.14.14.1
Pathway
rn00232  Caffeine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Orthology
K07409  cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]
K21724  7-methylxanthine demethylase [EC:1.14.13.128]

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