KEGG   ORTHOLOGY: K07409
Entry
K07409                      KO                                     
Symbol
CYP1A2
Name
cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00232  Caffeine metabolism
map00380  Tryptophan metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
Reaction
R03408  
R03629  melatonin,NADPH---hemoprotein reductase:oxygen oxidoreductase
R07000  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07001  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07021  1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07022  1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07055  
R07056  
R07098  trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07099  trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07939  caffeine:oxygen oxidoreductase (N3-demethylating)
R07943  
R07945  
R08293  
R08294  
R08392  
R09405  
R09407  
R09408  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
   00591 Linoleic acid metabolism
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
  09110 Biosynthesis of other secondary metabolites
   00232 Caffeine metabolism
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
   00982 Drug metabolism - cytochrome P450
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
   05207 Chemical carcinogenesis - receptor activation
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
   05208 Chemical carcinogenesis - reactive oxygen species
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP1 family
   K07409  CYP1A2; cytochrome P450 family 1 subfamily A2
Genes
HSA: 1544(CYP1A2)
PTR: 735881(CYP1A2)
PPS: 100975837(CYP1A2)
GGO: 101130358
PON: 100172368(CYP1A2)
PPYG: 129014441
NLE: 100586622
HMH: 116481901
SSYN: 129482258
MCF: 102130662(CYP1A2)
MTHB: 126959999
MNI: 105490960
CSAB: 103245329(CYP1A2)
CATY: 105600060
PANU: 101002117
TGE: 112627775
MLEU: 105530834
RRO: 104672152
RBB: 108531494
TFN: 117071589
PTEH: 111529709
CANG: 105505164
CJC: 100392712(CYP1A2)
SBQ: 101037899
ANAN: 105714471 135276964
CSYR: 103271647
MMUR: 105854822
LCAT: 123624379
PCOQ: 105807254
OGA: 100955723
MMU: 13077(Cyp1a2)
MCAL: 110301271
MPAH: 110328034
RNO: 24297(Cyp1a2)
MCOC: 116071962
ANU: 117698970
MUN: 110558530
CGE: 100755851
MAUA: 101825565
PROB: 127231801
PLEU: 114690345
MORG: 121445350 121445351 121445352
MFOT: 126507532 126507533 126507534
AAMP: 119808953 119808954 119808956
NGI: 103736875
CPOC: 100135513(Cyp1a2)
CCAN: 109695949
DORD: 105982353 105982354 105982355
DSP: 122098436 122098439
PLOP: 125368231
NCAR: 124977052
MMMA: 107137940
OCU: 100328937
TUP: 102484432
GVR: 103588056
CFA: 494010(CYP1A2)
CLUD: 112675583 112675584
VVP: 112917417
VLG: 121484959
NPO: 129506143
AML: 100472774
UMR: 103678991
UAH: 113240971
UAR: 123790681
ELK: 111153221
LLV: 125105139
MPUF: 101677117
MNP: 131999166
MLK: 131835777
NVS: 122893016
ORO: 101381962
EJU: 114206434
ZCA: 113910367
MLX: 118002935
NSU: 110584050
LWW: 102742108
FCA: 554345(CYP1A2)
PYU: 121041994
PCOO: 112855160
PBG: 122468422
PVIV: 125168378
LRUF: 124508017
PTG: 102966939
PPAD: 109262688
PUC: 125910173
AJU: 106979449
HHV: 120235751
BTA: 503552(CYP1A2)
BOM: 102280158
BIU: 109575670
BBUB: 102399561
BBIS: 104991054
CHX: 102170554
OAS: 101109214
BTAX: 128066814
ODA: 120875452
CCAD: 122419767
MBEZ: 129550128
SSC: 100152910(CYP1A2)
CFR: 102518362
CBAI: 105069191
CDK: 105087261
VPC: 102530734
BACU: 103007560
BMUS: 118891291
LVE: 103071784
OOR: 101287407
DLE: 111177607
PCAD: 102984795
PSIU: 116749085
NASI: 112410949
ECB: 100062244(CYP1A2)
EPZ: 103552315
EAI: 106831265
MYB: 102262040
MYD: 102761918
MMYO: 118675919
MLF: 102437484
MDT: 132226266
MNA: 107535217
DRO: 112301801
SHON: 118987676
AJM: 119046569
PDIC: 114492026
PHAS: 123825158
MMF: 118637248
HAI: 109396253
RFQ: 117022727
PGIG: 120597823
PVP: 111732470
MJV: 108388607
TOD: 119237889
SARA: 101544097
SETR: 126015076
LAV: 100666189
TMU: 101359541
ETF: 101661749
DNM: 101424165 101426385 101432104
MDO: 100029908
GAS: 123232968
SHR: 116421952
AFZ: 127551978
PCW: 110213926
TVP: 118828084
TCF: 131883248
MMER: 123552212
HSY: 130644429
 » show all
Reference
PMID:3755823
  Authors
Jaiswal AK, Nebert DW, Gonzalez FJ
  Title
Human P3(450): cDNA and complete amino acid sequence.
  Journal
Nucleic Acids Res 14:6773-4 (1986)
DOI:10.1093/nar/14.16.6773
  Sequence
[hsa:1544]
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