KEGG   REACTION: R08160
Entry
R08160                      Reaction                               
Name
L-tryptophan,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating)
Definition
L-Tryptophan + 2 [Reduced NADPH---hemoprotein reductase] + 2 Oxygen <=> Indole-3-acetaldehyde oxime + 2 [Oxidized NADPH---hemoprotein reductase] + CO2 + 3 H2O
Equation
C00078 + 2 C03024 + 2 C00007 <=> C02937 + 2 C03161 + C00011 + 3 C00001
Comment
three-step reaction (see R09583+R09584+R09585)
Reaction class
RC02295  C00078_C02937
Enzyme
1.14.14.156
Pathway
rn00380  Tryptophan metabolism
rn00966  Glucosinolate biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01210  2-Oxocarboxylic acid metabolism
Module
M00370  Glucosinolate biosynthesis, tryptophan => glucobrassicin
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.156
     R08160  L-Tryptophan + 2 [Reduced NADPH---hemoprotein reductase] + 2 Oxygen <=> Indole-3-acetaldehyde oxime + 2 [Oxidized NADPH---hemoprotein reductase] + CO2 + 3 H2O
Orthology
K11812  tryptophan N-monooxygenase [EC:1.14.14.156]
K11813  tryptophan N-monooxygenase [EC:1.14.14.156]
Other DBs
RHEA: 33282
LinkDB

KEGG   REACTION: R09583
Entry
R09583                      Reaction                               
Name
L-tryptophan,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating)
Definition
L-Tryptophan + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> N-Hydroxy-L-tryptophan + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C00078 + C03024 + C00007 <=> C19716 + C03161 + C00001
Comment
the first step of three-step reaction (see R08160, R09583+R09584+R09585)
Reaction class
RC00365  C00078_C19716
Enzyme
1.14.14.156
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.156
     R09583  L-Tryptophan + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> N-Hydroxy-L-tryptophan + [Oxidized NADPH---hemoprotein reductase] + H2O
Other DBs
RHEA: 25008
LinkDB

KEGG   REACTION: R09584
Entry
R09584                      Reaction                               
Name
N-hydroxy-L-tryptophan,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (N-hydroxylating)
Definition
N-Hydroxy-L-tryptophan + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> N,N-Dihydroxy-L-tryptophan + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C19716 + C03024 + C00007 <=> C19717 + C03161 + C00001
Comment
the second step of three-step reaction (see R08160, R09583+R09584+R09585)
Reaction class
RC01918  C19716_C19717
Enzyme
1.14.14.156
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.156
     R09584  N-Hydroxy-L-tryptophan + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> N,N-Dihydroxy-L-tryptophan + [Oxidized NADPH---hemoprotein reductase] + H2O
Other DBs
RHEA: 25012
LinkDB

KEGG   REACTION: R09585
Entry
R09585                      Reaction                               
Definition
N,N-Dihydroxy-L-tryptophan <=> Indole-3-acetaldehyde oxime + CO2 + H2O
Equation
C19717 <=> C02937 + C00011 + C00001
Comment
the last step of three-step reaction (see R08160, R09583+R09584+R09585)
Reaction class
RC01936  C02937_C19717
Enzyme
1.14.14.156
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.156
     R09585  N,N-Dihydroxy-L-tryptophan <=> Indole-3-acetaldehyde oxime + CO2 + H2O
Other DBs
RHEA: 25016
LinkDB

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