REACTION: R09259
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Entry
R09259 Reaction
Definition
3,5,7,9,11,13,15-Heptaoxo-hexadecanoyl-[acp] <=> 7,9,12-Octaketide intermediate 1
Equation
C12348
<=>
C18327
Reaction class
RC02545
C12348_C18327
Pathway
rn01056
Biosynthesis of type II polyketide backbone
rn01100
Metabolic pathways
rn01110
Biosynthesis of secondary metabolites
Module
M00778
Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide
Orthology
K05551
minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.-
2.3.1.260
2.3.1.235
]
K05552
minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.-
2.3.1.260
2.3.1.235
]
K05553
minimal PKS acyl carrier protein
Reference
1 [PMID:
15286722
]
Authors
Keatinge-Clay AT, Maltby DA, Medzihradszky KF, Khosla C, Stroud RM
Title
An antibiotic factory caught in action.
Journal
Nat Struct Mol Biol 11:888-93 (2004)
DOI:
10.1038/nsmb808
LinkDB
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