KEGG ORTHOLOGY: K05552

ORTHOLOGY: K05552

Entry

K05552                      KO

Symbol

actI2, oxyB, tcmL, snoa2, aknC, mtmK

Name

minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]

Pathway

map00253

Tetracycline biosynthesis

map01056

Biosynthesis of type II polyketide backbone

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00778

Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide

Reaction

R06635

R06637

R06641

R06643

R06644

R06645

R09258

R09259

R10960

malonyl-CoA:acetate malonyltransferase (tetracenomycin-F2-forming)

R11516

malonyl-CoA:malonamoyl-[acyl-carrier protein] malonyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01056 Biosynthesis of type II polyketide backbone
    K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
   00253 Tetracycline biosynthesis
    K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
   01008 Polyketide biosynthesis proteins
    K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.235  tetracenomycin F2 synthase
     K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
    2.3.1.260  tetracycline polyketide synthase
     K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
Lipid biosynthesis proteins [BR:ko01004]
Polyketide synthase
  Component type
   K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide synthase (PKS)
  Type II PKS
   C7-C14 cyclized polyketide type
    Octaketide PKS
     K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
    Nonaketide PKS
     K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)
    Decaketide PKS
     K05552  actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta)

Genes

MBD:	MEBOL_003041

PBRU:

LZC95_37905

PRUE:

LVJ94_37715 LVJ94_41860

PALJ:

LZC94_46820

MSAO:

MYCSP_12695

MSAL:

DSM43276_02542

NBR:	O3I_007450 O3I_015115

NNO:	NONO_c10800

NTP:	CRH09_08675

NOZ:	DMB37_03465

NAH:	F5544_10730 F5544_17025 F5544_31060

NIE:	KV110_14175

NTC:	KHQ06_30030

NYA:	LTV02_09615

NGP:	LTT66_26670

NSPU:

IFM12276_11090

NVU:	V7968_14840 V7968_22875

SCO:	SCO5088(SCBAC28G1.14)

SMA:	SAVERM_2375(pks9-3)

SFI:

SANL:

SGRF:

SCYE:

SSX:	SACTE_5203 SACTE_6347

SHY:

SHJG_1188

SHO:	SHJGH_1023

SFA:

Sfla_5317

SBH:

SBI_06845

SVE:

SVEN_5981

SDV:	BN159_2470 BN159_2514(tcmL)

SALS:

SLNWT_5122

STRP:

F750_1306(whiE-CLF)

SCI:	B446_13325

SLV:	SLIV_12945

SGU:	SGLAU_26360(tcmL) SGLAU_28975

SVT:	SVTN_18775 SVTN_28600

STRE:

GZL_p00215

SCW:	TU94_31830

SLD:	T261_0019 T261_6831

SXI:	SXIM_35600

STRM:

M444_36340

STRC:

AA958_14840 AA958_30260

SAMB:

SAM23877_0195(alpB) SAM23877_0207(alpQ) SAM23877_7466(alpQ) SAM23877_7478(alpB)

SPRI:

SPRI_0267 SPRI_0278 SPRI_7075 SPRI_7086

SCZ:	ABE83_16240

SCX:	AS200_01090

SRW:	TUE45_01296 TUE45_01569

STRF:

ASR50_01170 ASR50_34270

SPAV:

Spa2297_32725

SGS:	AVL59_46040

SGM:	GCM10017557_73760

SPHW:

NFX46_12165 NFX46_24980

SLS:	SLINC_6894

SALU:

DC74_6591

SALL:

SAZ_34275

STRD:

NI25_18960

SVU:	B1H20_09645

SPUN:

BFF78_19355

SLAU:

SLA_3073

SALJ:

SMD11_0676(actI2) SMD11_1144(actI2) SMD11_6045(actI2)

SLX:	SLAV_40240 SLAV_40515

SNZ:	DC008_13175

SGE:	DWG14_07359

SVQ:	N6Q81_34965 N6Q81_35025

SLK:	SLUN_33545

SDX:	C4B68_09600

SGD:	ELQ87_00820 ELQ87_08175

SCYA:

EJ357_29970 EJ357_34775

SNQ:	CP978_29745

STIR:

DDW44_27775

SKA:	CP970_02735 CP970_39680

SGZ:	C0216_31855

SNK:	CP967_10255

SHAW:

CEB94_23575

SRK:	FGW37_04260 FGW37_16270

SFIC:

EIZ62_03845

SGAL:

CP966_29075

SSPO:

DDQ41_07355

SVR:	CP971_23920

SFY:	GFH48_20450

SAQU:

EJC51_31360

SGF:	HEP81_07942

SCAV:

CVT27_18215

SRIM:

CP984_02380

SCIN:

CP977_28050

SPAC:

B1H29_00520 B1H29_36540

STSU:

B7R87_22040

SCHA:

CP983_03645 CP983_27890

SGX:	H4W23_11745

SCOE:

CP976_32910

SBAT:

G4Z16_23875

SSPB:

CP982_19000

SNF:	JYK04_04013

SPLA:

CP981_11515 CP981_34525

STUI:

SCHF:

SHUN:

SHAR:

SCYG:

SFEU:

SLIA:

SDW:	K7C20_32765

SCAL:

SAUH:

SMOB:

SPEU:

SROI:

IAG44_09610 IAG44_37960 IAG44_41435

SXN:	IAG42_35945 IAG42_36720

SHK:	J2N69_28360

SANU:

K7396_04305

SDD:	D9753_08530

SACT:

SMAO:

SGOB:

SINE:

SLF:	JEQ17_32815

SDEC:

SDUR:

SYAN:

STAA:

SNIG:

SSPN:

SCIR:

STRCI_006079 STRCI_006122

SLON:

LGI35_31855

SDRZ:

NEH16_30130 NEH16_32490

STUD:

STRTU_005095

SGK:	PET44_33780

SARG:

HKX69_34110

SJN:	RI060_18275

SCYN:

N8I84_12670

SOV:	QZH56_16780 QZH56_23790

SHAU:

K9S39_40680

SKG:	KJK29_16070

STTN:

BSL84_24940

SINN:

ABB07_18370

KBU:	Q4V64_27185

SARM:

DVA86_07640

STPB:

QR97_20405 QR97_38785

SRPA:

SMIB:

SCAJ:

STRL:

STSD:

HEP87_27715 HEP87_54595

SRPZ:

HEP85_21130

SCHE:

QRN89_14890

SGLY:

P8A20_30985 P8A20_33850

SCAT:

STII:

STIC:

SABD:

STRV:

SMOD:

STBR:

STAC:

SSOC:

ABZO31_11615 ABZO31_28400

SSLI:

SCIT:

SSIR:

SFLU:

SSTO:

SLUA:

STGO:

STCM:

SCMC78_30130 SCMC78_30510

STCZ:

JHY03_07210 JHY03_37990

STHU:

M1P56_12305 M1P56_20575

SSEC:

ABZO29_24880

STRK:

R2B38_43145

KAB:	B7C62_31270

KAU:	B6264_18495

KIT:	CFP65_4149

KIS:	HUT16_23690

KCH:	O1G21_22140

KCM:	ABWK59_25945

KNB:	ACF9IK_31775

KPUR:

ACFCLZ_05795 ACFCLZ_25865

YIA:	LO772_34315

STRH:

GXP74_03140

ABRY:

NYE86_15465 NYE86_15940

AGLA:

OIE69_26825

AREV:

RVR_1656 RVR_2904 RVR_8893

RATH:

LMOI:

TFU:

TALX:

NOCB:

TCU:

AGRA:

ACIR:

OG979_01950 OG979_20965 OG979_36255

AWS:	ACN3XK_69240

SPIQ:

OHA34_06340

SRO:

Sros_4151

NOA:	BKM31_22870

NCX:	Nocox_12790

FRA:	Francci3_4100 Francci3_4148

FRI:	FraEuI1c_1318

SVI:	Svir_33700

AMD:	AMED_5434(fabF)

AMN:

RAM_27700

AMM:	AMES_5369(fabF)

AMZ:	B737_5369(fabF)

AORI:

SD37_09330 SD37_34300

APRT:

ACYN:

ACOR:

AMYS:

PSEQ:

PECQ:

PHH:	AFB00_31130

PSDS:

K1T35_37460

PALQ:

PaSha_27265

SESP:

BN6_54870

SSYI:

EKG83_16315 EKG83_32215

KAL:

KALB_7830

KUT:	JJ691_15660

KBR:	Q4V65_05445 Q4V65_06785 Q4V65_18880

KPHY:

AOZ06_32110

LED:	BBK82_02450

LXR:	ACRSBM_30230

AHM:	TL08_10470

ACTI:

UA75_11095

ACAD:

UA74_11005

AHG:	AHOG_10350

ACTA:

ACAU:

ALO:

PMAD:

ACTU:

CROS:

STP:	Strop_2224

MAU:	Micau_4018

MIL:

ML5_4403

MICH:

FJK98_03845

MSAG:

GCM10017556_44980

VMA:	VAB18032_18170

VER:	HUT12_05335

MENO:

Jiend_01490

MCHL:

PVK74_07695

MFEU:

H1D33_23035 H1D33_25695

MHAW:

RMN56_24400

MCAY:

PVK37_16755 PVK37_21255 PVK37_24375

MICF:

QQG74_18955

MICN:

WHN02_18145

VET:	ACQVFL_11585 ACQVFL_17360

AMS:	AMIS_50420 AMIS_50650

ACTN:

L083_3108

AIH:	Aiant_86570(fabF_3)

ACTR:

Asp14428_76460(fabF_3)

ACTL:

L3i22_085320

PLK:	CIK06_11010

CATI:

CS0771_73190

DVC:	Dvina_17885

DFU:	Dfulv_18395

DROS:

Drose_14745 Drose_24330

DAUR:

Daura_28645 Daura_37855

DACT:

KZZ52_34425

NHY:	JQS43_06230

CCAZ:

COUCH_16060

CAI:	Caci_3547 Caci_6486

KBB:	ccbrp13_66820(fabF_2)

AG:	AAA65207(dpsB) AAF70107(aknC) AAG30188(zhuA) AAZ78326(oxyB) CAA12018(snoa2) CAA61990(mtmK)

» show all

Reference

PMID:1527048

Authors

Fernandez-Moreno MA, Martinez E, Boto L, Hopwood DA, Malpartida F

Title

Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.

Journal

J Biol Chem 267:19278-90 (1992)
DOI:10.1016/S0021-9258(18)41772-3

Sequence

[sco:SCO5088]

Reference

PMID:16597959

Authors

Zhang W, Ames BD, Tsai SC, Tang Y

Title

Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.

Journal

Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006

Sequence

[ag:AAZ78326]

Reference

PMID:20522541

Authors

Pickens LB, Tang Y

Title

Oxytetracycline biosynthesis.

Journal

J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419

Reference

PMID:2684656

Authors

Bibb MJ, Biro S, Motamedi H, Collins JF, Hutchinson CR

Title

Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.

Journal

EMBO J 8:2727-36 (1989)
DOI:10.1002/j.1460-2075.1989.tb08414.x

Sequence

[sgu:SGLAU_26360]

Reference

PMID:8668120

Authors

Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mantsala P

Title

A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.

Journal

Mol Gen Genet 251:113-20 (1996)
DOI:10.1007/BF02172908

Sequence

[ag:CAA12018]

Reference

PMID:8654997

Authors

Lombo F, Blanco G, Fernandez E, Mendez C, Salas JA

Title

Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.

Journal

Gene 172:87-91 (1996)
DOI:10.1016/0378-1119(96)00029-7

Sequence

[ag:CAA61990]

LinkDB

DBGET integrated database retrieval system