KEGG   REACTION: R09420
Entry
R09420                      Reaction                               
Name
carbonyl reductase
Definition
4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone + NADPH + H+ <=> 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol + NADP+
Equation
C16453 + C00005 + C00080 <=> C19574 + C00006
Reaction class
RC00001  C00005_C00006
RC01491  C16453_C19574
Enzyme
1.1.1.146       1.1.1.184       1.3.1.20
Pathway
rn00980  Metabolism of xenobiotics by cytochrome P450
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.146
     R09420  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone + NADPH + H+ <=> 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol + NADP+
    1.1.1.184
     R09420  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone + NADPH + H+ <=> 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol + NADP+
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.20
     R09420  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone + NADPH + H+ <=> 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol + NADP+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.184
   R03557  Secondary alcohol <=> Ketone
    R09420  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol <=> 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
Orthology
K00079  carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197]
K00081  carbonyl reductase 2 [EC:1.1.1.184]
K00084  carbonyl reductase 3 [EC:1.1.1.184]
K00212  20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase [EC:1.1.1.149 1.1.1.357 1.3.1.20]
K15680  corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:1.1.1.146]
LinkDB

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