KEGG   REACTION: R09720
Entry
R09720                      Reaction                               
Name
(R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate-forming]
Definition
(R)-2-Hydroxybutane-1,2,4-tricarboxylate <=> Homoisocitrate
Equation
Comment
two-step reaction (see R03444+R04371)
Reaction class
RC00497  C01251_C05662
Enzyme
Pathway
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
rn01240  Biosynthesis of cofactors
Module
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.114
     R09720  (R)-2-Hydroxybutane-1,2,4-tricarboxylate <=> Homoisocitrate
Orthology
K16792  methanogen homoaconitase large subunit [EC:4.2.1.114]
K16793  methanogen homoaconitase small subunit [EC:4.2.1.114]
Other DBs
RHEA: 32306
LinkDB

KEGG   RCLASS: RC00497
Entry
RC00497                     RClass                                 
Definition
C1b-C1c:*-O1a:C1d+C6a-C1c+C6a
C1d-C1c:O1a-*:C1b+C1b+C6a-C1b+C1c+C6a
O1a-O1a:C1d+*-*+C1c:*-*
Reactant pair
Related class
Reaction
Enzyme
4.2.1.3         4.2.1.114       4.2.1.166       4.2.1.170       
4.2.1.-
Pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn00440  Phosphonate and phosphinate metabolism
rn00966  Glucosinolate biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
rn01240  Biosynthesis of cofactors
RModule
RM001  2-Oxocarboxylic acid chain extension by tricarboxylic acid pathway
Orthology
K01681  aconitate hydratase [EC:4.2.1.3]
K01682  aconitate hydratase 2 / 2-methylisocitrate dehydratase [EC:4.2.1.3 4.2.1.99]
K01703  3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35]
K16792  methanogen homoaconitase large subunit [EC:4.2.1.114]
K16793  methanogen homoaconitase small subunit [EC:4.2.1.114]
K17749  3-benzylmalate isomerase [EC:4.2.1.-]
K20930  phosphinomethylmalate isomerase [EC:4.2.1.166]
K21359  3-isopropylmalate/methylthioalkylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.170]
K27802  aconitate hydratase A / 2-methylisocitrate dehydratase [EC:4.2.1.3 4.2.1.99]

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