KEGG   REACTION: R10453
Entry
R10453                      Reaction                               
Name
3-dimethylallyl-4-hydroxybenzoate:3-amino-4,7-dihydroxycoumarin ligase (AMP-forming)
Definition
ATP + 3-Dimethylallyl-4-hydroxybenzoate + 3-Amino-4,7-dihydroxycoumarin <=> AMP + Diphosphate + 8-Demethylnovobiocic acid
Equation
C00002 + C12458 + C12468 <=> C00020 + C00013 + C20629
Reaction class
RC00162  C12458_C20629
RC00416  C12468_C20629
Enzyme
6.3.1.15
Pathway
rn00401  Novobiocin biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.1  Acid-D-ammonia (or amine) ligases (amide synthases)
    6.3.1.15
     R10453  ATP + 3-Dimethylallyl-4-hydroxybenzoate + 3-Amino-4,7-dihydroxycoumarin <=> AMP + Diphosphate + 8-Demethylnovobiocic acid
Orthology
K12709  8-demethylnovobiocic acid synthase [EC:6.3.1.15]
Other DBs
RHEA: 36702
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