KEGG   REACTION: R12066
Entry
R12066                      Reaction                               
Name
[LarE]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl]-L-cysteine pyridin-1-ium-3,5-dicarbothioate-mononucleotide-lyase (ATP-consuming)
Definition
[Protein]-L-cysteine + Pyridinium-3-carboxy-5-thiocarboxylic acid mononucleotide + ATP <=> [Protein]-dehydroalanine + Pyridinium-3,5-biscarboxylic acid mononucleotide + AMP + Diphosphate
Equation
C02743 + C21878 + C00002 <=> C21861 + C21851 + C00020 + C00013
Comment
three-step reaction (R12063+R12064+R12065)
Enzyme
4.4.1.37
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.4  Carbon-sulfur lyases
   4.4.1  Carbon-sulfur lyases (only sub-subclass identified to date)
    4.4.1.37
     R12066  [Protein]-L-cysteine + Pyridinium-3-carboxy-5-thiocarboxylic acid mononucleotide + ATP <=> [Protein]-dehydroalanine + Pyridinium-3,5-biscarboxylic acid mononucleotide + AMP + Diphosphate
Orthology
K06864  cysteine-dependent pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase [EC:4.4.1.37 4.4.1.45]
LinkDB

KEGG   REACTION: R12053
Entry
R12053                      Reaction                               
Name
aurachin-B,NADH:oxygen oxidoreductase (2',3'-epoxidizing)
Definition
Aurachin B + NADH + H+ + Oxygen <=> Aurachin B epoxide + NAD+ + H2O
Equation
C21140 + C00004 + C00080 + C00007 <=> C21874 + C00003 + C00001
Reaction class
RC03133  C21140_C21874
Enzyme
1.14.13.-
Pathway
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00848  Aurachin biosynthesis, anthranilate => aurachin A
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.-
     R12053  Aurachin B + NADH + H+ + Oxygen <=> Aurachin B epoxide + NAD+ + H2O
Orthology
K22801  aurachin B monooxygenase [EC:1.14.13.-]
LinkDB

KEGG   REACTION: R12064
Entry
R12064                      Reaction                               
Definition
1-(5-O-Phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl adenylate + [Protein]-L-cysteine <=> AMP + [Protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl]-L-cysteine
Equation
C21879 + C02743 <=> C00020 + C21881
Comment
the second step of three-step reaction (see R12066, R12053+R12064+R12065)
Reaction class
RC00004  C02743_C21881
RC00070  C00020_C21879
Enzyme
4.4.1.37
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.4  Carbon-sulfur lyases
   4.4.1  Carbon-sulfur lyases (only sub-subclass identified to date)
    4.4.1.37
     R12064  1-(5-O-Phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl adenylate + [Protein]-L-cysteine <=> AMP + [Protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl]-L-cysteine
Orthology
K06864  cysteine-dependent pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase [EC:4.4.1.37 4.4.1.45]
LinkDB

KEGG   REACTION: R12065
Entry
R12065                      Reaction                               
Definition
[Protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl]-L-cysteine <=> [Protein]-dehydroalanine + Pyridinium-3,5-bisthiocarboxylate mononucleotide
Equation
C21881 <=> C21861 + C21767
Comment
the last step of three step reaction (see R12066, R12063+R12064+R12065)
Reaction class
RC03225  C21767_C21881
RC03525  C21861_C21881
Enzyme
4.4.1.37
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.4  Carbon-sulfur lyases
   4.4.1  Carbon-sulfur lyases (only sub-subclass identified to date)
    4.4.1.37
     R12065  [Protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium-3-carbonyl]-L-cysteine <=> [Protein]-dehydroalanine + Pyridinium-3,5-bisthiocarboxylate mononucleotide
Orthology
K06864  cysteine-dependent pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase [EC:4.4.1.37 4.4.1.45]
LinkDB

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