KEGG   REACTION: R12118
Entry
R12118                      Reaction                               
Name
sterol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (14-methyl cleaving)
Definition
14alpha-Methylsteroid + 3 [Reduced NADPH---hemoprotein reductase] + 3 Oxygen <=> Delta14-Steroid + Formate + 3 [Oxidized NADPH---hemoprotein reductase] + 4 H2O
Equation
C21918 + 3 C03024 + 3 C00007 <=> C21919 + C00058 + 3 C03161 + 4 C00001
Comment
three-step reaction (see R12119+R12120+R12121)
Enzyme
1.14.14.154
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.154
     R12118  14alpha-Methylsteroid + 3 [Reduced NADPH---hemoprotein reductase] + 3 Oxygen <=> Delta14-Steroid + Formate + 3 [Oxidized NADPH---hemoprotein reductase] + 4 H2O
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.14.14.154
   R12118  14alpha-Methylsteroid <=> Delta14-Steroid
Other DBs
RHEA: 54031
LinkDB

KEGG   REACTION: R12119
Entry
R12119                      Reaction                               
Definition
14alpha-Methylsteroid + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 14alpha-Hydroxymethylsteroid + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C21918 + C03024 + C00007 <=> C21920 + C03161 + C00001
Comment
the first step of three-step reaction (see R12118, R12119+R12120+R12121)
Reaction class
RC00257  C21918_C21920
Enzyme
1.14.14.154
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.154
     R12119  14alpha-Methylsteroid + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 14alpha-Hydroxymethylsteroid + [Oxidized NADPH---hemoprotein reductase] + H2O
Other DBs
RHEA: 68063
LinkDB

KEGG   REACTION: R12120
Entry
R12120                      Reaction                               
Definition
14alpha-Hydroxymethylsteroid + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 14alpha-Formylsteroid + [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Equation
C21920 + C03024 + C00007 <=> C21921 + C03161 + 2 C00001
Comment
the second step of three-step reaction (see R12118, R12119+R12120+R12121)
Reaction class
RC00893  C21920_C21921
Enzyme
1.14.14.154
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.154
     R12120  14alpha-Hydroxymethylsteroid + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> 14alpha-Formylsteroid + [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Other DBs
RHEA: 68067
LinkDB

KEGG   REACTION: R12121
Entry
R12121                      Reaction                               
Definition
14alpha-Formylsteroid + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Delta14-Steroid + Formate + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C21921 + C03024 + C00007 <=> C21919 + C00058 + C03161 + C00001
Comment
the last step of three-step reaction (see R12118, R12119+R12120+R12121)
Enzyme
1.14.14.154
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.154
     R12121  14alpha-Formylsteroid + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Delta14-Steroid + Formate + [Oxidized NADPH---hemoprotein reductase] + H2O
Other DBs
RHEA: 68071
LinkDB

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