KEGG   REACTION: R12378
Entry
R12378                      Reaction                               
Name
24-methylenelophenol,ferrocytochrome-b5:oxygen oxidoreductase (C-4alpha-methyl-hydroxylating)
Definition
24-Methylenelophenol + 6 Ferrocytochrome b5 + 3 Oxygen + 6 H+ <=> 3beta-Hydroxyergosta-7,24(24(1))-dien-4alpha-carboxylate + 6 Ferricytochrome b5 + 4 H2O
Equation
C11522 + 6 C00999 + 3 C00007 + 6 C00080 <=> C22119 + 6 C00996 + 4 C00001
Comment
three-step reaction (see R12372+R12373+R12374)
Reaction class
RC03537  C11522_C22119
Enzyme
1.14.18.11
Pathway
rn00100  Steroid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00917  Phytosterol biosynthesis, squalene 2,3-epoxide => campesterol/sitosterol
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.18  With another compound as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.18.11
     R12378  24-Methylenelophenol + 6 Ferrocytochrome b5 + 3 Oxygen + 6 H+ <=> 3beta-Hydroxyergosta-7,24(24(1))-dien-4alpha-carboxylate + 6 Ferricytochrome b5 + 4 H2O
Orthology
K14424  plant 4alpha-monomethylsterol monooxygenase [EC:1.14.18.11]
LinkDB

KEGG   REACTION: R12372
Entry
R12372                      Reaction                               
Name
24-methylenelophenol,ferrocytochrome-b5:oxygen oxidoreductase
Definition
24-Methylenelophenol + 2 Ferrocytochrome b5 + Oxygen + 2 H+ <=> 4alpha-(Hydroxymethyl)ergosta-7,24(24(1))-dien-3beta-ol + 2 Ferricytochrome b5 + H2O
Equation
C11522 + 2 C00999 + C00007 + 2 C00080 <=> C22117 + 2 C00996 + C00001
Comment
the first step of three-step reaction (see R12378, R12372+R12373+R12374)
Reaction class
RC03228  C11522_C22117
Enzyme
1.14.18.11
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.18  With another compound as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.18.11
     R12372  24-Methylenelophenol + 2 Ferrocytochrome b5 + Oxygen + 2 H+ <=> 4alpha-(Hydroxymethyl)ergosta-7,24(24(1))-dien-3beta-ol + 2 Ferricytochrome b5 + H2O
LinkDB

KEGG   REACTION: R12373
Entry
R12373                      Reaction                               
Name
4alpha-(hydroxymethyl)ergosta-7,24(241)-dien-3beta-ol,ferrocytochrome-b5:oxygen oxidoreductase
Definition
4alpha-(Hydroxymethyl)ergosta-7,24(24(1))-dien-3beta-ol + 2 Ferrocytochrome b5 + Oxygen + 2 H+ <=> 4alpha-Formylergosta-7,24(24(1))-dien-3beta-ol + 2 Ferricytochrome b5 + 2 H2O
Equation
C22117 + 2 C00999 + C00007 + 2 C00080 <=> C22118 + 2 C00996 + 2 C00001
Comment
the second step of three-step reaction (see R12378, R12372+R12373+R12374)
Reaction class
RC00450  C22117_C22118
Enzyme
1.14.18.11
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.18  With another compound as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.18.11
     R12373  4alpha-(Hydroxymethyl)ergosta-7,24(24(1))-dien-3beta-ol + 2 Ferrocytochrome b5 + Oxygen + 2 H+ <=> 4alpha-Formylergosta-7,24(24(1))-dien-3beta-ol + 2 Ferricytochrome b5 + 2 H2O
LinkDB

KEGG   REACTION: R12374
Entry
R12374                      Reaction                               
Name
4alpha-formylergosta-7,24(24(1))-dien-3beta-ol,ferrocytochrome-b5:oxygen oxidoreductase
Definition
4alpha-Formylergosta-7,24(24(1))-dien-3beta-ol + 2 Ferrocytochrome b5 + Oxygen + 2 H+ <=> 3beta-Hydroxyergosta-7,24(24(1))-dien-4alpha-carboxylate + 2 Ferricytochrome b5 + H2O
Equation
C22118 + 2 C00999 + C00007 + 2 C00080 <=> C22119 + 2 C00996 + C00001
Comment
the last step of three-step reaction (see R12378, R12372+R12373+R12374)
Reaction class
RC01453  C22118_C22119
Enzyme
1.14.18.11
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.18  With another compound as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.18.11
     R12374  4alpha-Formylergosta-7,24(24(1))-dien-3beta-ol + 2 Ferrocytochrome b5 + Oxygen + 2 H+ <=> 3beta-Hydroxyergosta-7,24(24(1))-dien-4alpha-carboxylate + 2 Ferricytochrome b5 + H2O
LinkDB

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