Canis lupus familiaris (dog): 403444 Help Entry 403444            CDS       T01007                                  Symbol TH Name (RefSeq) tyrosine 3-monooxygenase   KO K00501   tyrosine 3-monooxygenase [EC:1.14.16.2] Organism cfa  Canis lupus familiaris (dog) Pathway cfa00350   Tyrosine metabolism cfa00790   Folate biosynthesis cfa01100   Metabolic pathways cfa04728   Dopaminergic synapse cfa04917   Prolactin signaling pathway cfa05012   Parkinson disease cfa05030   Cocaine addiction cfa05031   Amphetamine addiction cfa05034   Alcoholism Module cfa_M00042   Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline Brite KEGG Orthology (KO) [BR:cfa00001]  09100 Metabolism   09105 Amino acid metabolism    00350 Tyrosine metabolism     403444 (TH)   09108 Metabolism of cofactors and vitamins    00790 Folate biosynthesis     403444 (TH)  09150 Organismal Systems   09152 Endocrine system    04917 Prolactin signaling pathway     403444 (TH)   09156 Nervous system    04728 Dopaminergic synapse     403444 (TH)  09160 Human Diseases   09164 Neurodegenerative disease    05012 Parkinson disease     403444 (TH)   09165 Substance dependence    05030 Cocaine addiction     403444 (TH)    05031 Amphetamine addiction     403444 (TH)    05034 Alcoholism     403444 (TH) Enzymes [BR:cfa01000]  1. Oxidoreductases   1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen    1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor     1.14.16.2  tyrosine 3-monooxygenase      403444 (TH) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Biopterin_H TH_ACT TOH_N LTP_2 Motif Other DBs NCBI-GeneID:  403444 NCBI-ProteinID:  NP_001002966 Ensembl:  ENSCAFG00000010099 VGNC:  47322 UniProt:  Q76IQ3 LinkDB All DBs Position 18:complement(44936923..44944750) Genome browser AA seq 495 aa AA seqDB search MPTPNTASPQAKGFRRAVSELDAKQAEAIMSPRFIGRRQSLIEDARKEREKAEAASAASS EPGDLLEAAVSKEKDGKAMLNLLFTLRGAKTSSLSRAVKAFETFEAQIHHLETRPVQRPR AGGPHLEYFVRCEVPSADLPALLSSVRRVAEDVRGAGENKVLWFPRKVSELDKCHHLVTK FDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHGDPIPRVEYTAEEIATWKEVYTTLKSL YVTHACREHLEAFQLLERFSGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLAS LAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEE IEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHSLSEEPEIRAFDPDAAAVQPY QDQTYQSVYFVSESFSDAKDKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHAIRRSLEGV QDELHTLAHALSAIG NT seq 1488 nt NT seq  +upstreamnt  +downstreamnt atgcccactcccaacaccgcctcgccgcaggccaagggcttccgcagggctgtctcggag ctggacgccaagcaggccgaagccatcatgtccccgcgcttcatcgggcggcgccagagc ctcattgaggacgcacgcaaggagcgagagaaagcagaggccgcgtcggctgcctcctcg gagcccggagacctcctggaggccgcggtgtccaaggagaaggacgggaaggccatgctg aacttgctcttcaccctgcggggcgccaagacctcttcgctgtcccgagccgtgaaggca tttgagacgtttgaagcccaaatccaccatctggagacccggcccgtccagaggccacgg gcagggggcccccacctggagtactttgtgcgctgtgaggtgcccagtgctgacctgccc gccctgctcagctccgtgcgccgggtggcggaggatgtgcgtggtgccggggagaacaag gtcctctggttcccaaggaaagtttctgagctggacaagtgccaccatctagtcaccaag tttgaccctgacctggacttggatcacccgggcttctcggaccaggtgtaccgccagcgc aggaagctgattgcagagatcgcattccaatacaagcatggtgaccccattccccgagtg gagtacacggccgaggagattgccacctggaaggaggtctacaccaccctgaaaagcctg tatgtgacccatgcctgccgggagcacctggaggccttccagctgctggagcgcttcagc gggtaccgtgaggacagcatcccccagctggaggacgtgtcccgcttcctgaaggagcgg acaggcttccagctgcggcccgtggccggtctgctgtccgcaagggacttcctggccagc ctggccttccgagtgttccagtgcacgcagtacatccggcacgcgtcctcacccatgcac tcccccgagccggactgctgtcatgagctgctggggcacgtgcccatgctggctgaccgg accttcgctcagttttcccaggacattgggctcgcgtccttgggggcttctgatgaggaa attgagaagctgtccacgctgtactggttcacagtggagttcgggctgtgcaagcagaat ggtgaggtgaaggcctatggcgctgggctgctgtcctcctacggggagctcctgcactcc ctgtctgaggagcccgagatccgggccttcgacccagacgctgcggccgtgcagccttac caggaccagacctaccagtcggtctactttgtgtctgaaagcttcagcgatgccaaggac aagctcaggaactacgcttcccgcatccaacgccccttctccgtgaagttcgacccatat acgctggccatcgacgtgctggacagtccccacgccatccggcgctcgctggagggggtc caggacgagctgcacaccctcgcccatgcgctcagcgccatcggctag

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