KEGG   Canis lupus familiaris (dog): 497070
Entry
497070            CDS       T01007                                 
Symbol
AKR1C3
Name
(RefSeq) aldo-keto reductase family 1 member C21
  KO
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa00140  Steroid hormone biosynthesis
cfa00590  Arachidonic acid metabolism
cfa00790  Folate biosynthesis
cfa01100  Metabolic pathways
cfa04913  Ovarian steroidogenesis
cfa05208  Chemical carcinogenesis - reactive oxygen species
Module
cfa_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
cfa_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    497070 (AKR1C3)
   00590 Arachidonic acid metabolism
    497070 (AKR1C3)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    497070 (AKR1C3)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    497070 (AKR1C3)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    497070 (AKR1C3)
Enzymes [BR:cfa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51  3(or 17)beta-hydroxysteroid dehydrogenase
     497070 (AKR1C3)
    1.1.1.188  prostaglandin-F synthase
     497070 (AKR1C3)
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     497070 (AKR1C3)
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     497070 (AKR1C3)
SSDB
Motif
Pfam: Aldo_ket_red
Other DBs
NCBI-GeneID: 497070
NCBI-ProteinID: NP_001012344
Ensembl: ENSCAFG00000005276
UniProt: A0A8C0LYD8 Q5FYA7
LinkDB
Position
2:27694812..27719595
AA seq 324 aa
MNLMKLRSVKLNDGLSMPPLGFGTSAPSKVPKTEVEEAVKRAIDVGYRHFDSAYMYLNEE
EIGRAIQRKIADGTVKREDIFYTSKVWVTFLRPELVQTNLEMSLKKLGFSYVDLYLIHFP
VPLKPGEELFPKDKDGKIIFDRVDLCATWEAMEKCKDSGLAKSIGVSNFNRRQLERILSK
PRLKYKPVCNQVECHLYFNQSKLLEFCKSKDIILTAYGALGSDFGKEWVNQDAPVLLKDP
VLNAVAARHGRTPAQVALRFQLQRGVVALAKSFNEKRIRENFQVFDFQLTPEDMETLSSL
NKNIRYFSDTLFATHPDYPFNDED
NT seq 975 nt   +upstreamnt  +downstreamnt
atgaatctaatgaaacttagatctgtaaagctgaacgatggactcagcatgcctccactg
ggatttggcacctctgctcctagcaaggttcctaagactgaagtggaagaggccgtcaag
agagcaatcgatgtaggctaccgccattttgactcagcctatatgtatctcaatgaagaa
gagattgggagggccatccagaggaagattgctgatggcactgtgaagagagaggacata
ttctacacttcgaaggtgtgggtaaccttcctccgtccagaattggttcaaaccaatcta
gaaatgtcactgaagaagcttgggtttagctatgtggatctttatctcattcatttccca
gtacctttgaagcctggggaggaattgttcccaaaggacaaagatggaaaaatcattttt
gacagagtggatctctgtgccacatgggaggccatggagaagtgtaaagattcagggctt
gccaagtctattggtgtgtccaactttaaccgcaggcagctggagaggatcctgagcaag
ccaaggcttaagtacaagcctgtctgcaaccaggtggagtgtcacctttacttcaaccag
agcaaactcctggagttctgcaagtccaaggacatcatcctgactgcatacggtgccttg
gggtccgacttcgggaaggaatgggtgaaccaggacgccccagttctcctgaaggaccca
gttctcaatgctgtggccgccaggcacgggcgaactccggcccaggtggccctgcgcttc
cagctgcagcggggggtggtggccttggccaagagcttcaacgagaagagaatccgggag
aacttccaggtgtttgatttccagttgacaccagaggacatggagactctgagcagcctc
aacaaaaacattcgctacttttcagatactttatttgctactcatccggattatccattt
aatgacgaggattaa

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