KEGG   ENZYME: 1.1.1.51
Entry
EC 1.1.1.51                 Enzyme                                 
Name
3(or 17)beta-hydroxysteroid dehydrogenase;
beta-hydroxy steroid dehydrogenase;
17-ketoreductase;
17beta-hydroxy steroid dehydrogenase;
3beta-hydroxysteroid dehydrogenase;
3beta-hydroxy steroid dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase
Reaction(IUBMB)
testosterone + NAD(P)+ = androstenedione + NAD(P)H + H+ [RN:R01836 R01838]
Reaction(KEGG)
R01836 R01838;
(other) R02352 R02353 R03406 R03407 R09956 R09957 R13039 R13219 R13220 R13221
Substrate
testosterone [CPD:C00535];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
androstenedione [CPD:C00280];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts on other 3beta- or 17beta-hydroxysteroids. cf. EC 1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase.
History
EC 1.1.1.51 created 1961
Pathway
ec00140  Steroid hormone biosynthesis
ec00984  Steroid degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04119  aldo-keto reductase family 1 member C3
K05296  3(or 17)beta-hydroxysteroid dehydrogenase
Genes
HSA: 8644(AKR1C3)
PTR: 100612718(AKR1C3) 100612887 746545
PPS: 100971300 100986388(AKR1C3) 100987632 100988315
GGO: 101144878(AKR1C3) 101147265(AKR1C8) 101152195
PON: 100174617(AKR1C3) 100432652 100461633 100462259
PPYG: 129006137 129006869 129006873 129006874(AKR1C8)
NLE: 100593325 100604844 100606512
HMH: 116457717 116460197(AKR1C8)
SSYN: 129491831 129491837 129491838
MCC: 100430336 711440 722485 722496
MCF: 102116465 102142023(HSD17B5) 102143072 102144231
MTHB: 126963005 126963008 126963422
MNI: 105490778 105490780 105490783 105494391 112428206
CSAB: 103237812 103237813 103237816
CATY: 105587690 105597446 105597481
PANU: 100997485 101022585 101024707
TGE: 112631307 112631750
MLEU: 105532496 105535734 105535762
RRO: 104674747 104678924
RBB: 108521036 108532990
TFN: 117082052 117082118 117083437
PTEH: 111528130 111528985 113224919
CANG: 105521700 105521704
CJC: 100406962 100409025 100409384
SBQ: 101041594 101042225 101049957
CIMI: 108285106 108292323 108292357
ANAN: 105710839 105710887 105710891
CSYR: 103261879 103261880 103261882 103261883 103263298 103263300
MMUR: 105858219 105858220 105858221 105858224
LCAT: 123623042 123623043 123623044 123623047
PCOQ: 105826891 105826910 105826913
OGA: 100942491 100967071
MCAL: 110308148
MPAH: 110333839 110333848
RNO: 361267(Akr1c15)
MCOC: 116081731
ANU: 117713832
MUN: 110560700
CGE: 100768090 100768376
MAUA: 101841267
PROB: 127229800
PLEU: 114708096
MORG: 121432600 121432606 121432658 121432668
MFOT: 126501679 126501680 126501681 126506800
AAMP: 119816160 119816243 119826549
NGI: 103725884 103725890 103725892 103746652
HGL: 101702106
CPOC: 100727454
CCAN: 109678869 109680334 109680990
DSP: 122113031
PLOP: 125366785
NCAR: 124961142 124961655
OCU: 108176284
OPI: 101524567 101525842 101526664 101526901 101527313 101527569 101527977
TUP: 102478063 102478495 102491222 102491650
GVR: 103602898 103610229 103610426
CFA: 497070(AKR1C3)
CLUD: 112658979
VVP: 112933725
VLG: 121496638
NPO: 129514265
AML: 100483758
UMR: 103676234
UAH: 113241124
UAR: 123802294(AKR1C8)
ELK: 111158636
LLV: 125107753
MPUF: 101678776
MNP: 132020017
MLK: 131838054
NVS: 122891768(AKR1C4)
ORO: 101377633 101379669
EJU: 114217720
ZCA: 113921662
MLX: 118021623 118021905
LWW: 102748666 102748964
FCA: 100510801(AKR1C3)
PYU: 121014878
PCOO: 112867557
PBG: 122473163
PVIV: 125169528
LRUF: 124502362
PTG: 102963188
PPAD: 109273789
PUC: 125918575
AJU: 106988139
HHV: 120237198
BTA: 100139386(20ALPHA-HSD) 112441538 112449293 282138(AKR1C4) 506594 527068 538060 617917(AKR1C3) 782884
BOM: 102267155 102269337 102271453 102271733 102272308 102272594 102272882 102273443 102283454 102284205
BIU: 109567627 109568074 109568076 109568077 109568079 109568080 109568087
BBUB: 102389138 102395293 102395635 102396460 102396772 102400645 102404780 102415234 102416534
BBIS: 104985980 104985985 104985990 104985991 104985992 104985994 104985995 104985998 104985999 104986133
CHX: 102176340 102176622 102177638 102186942 102187204 102187504 102187932 102188418 102188684 102189109 102189495 102190498
OAS: 101107119 101107541 101107809 101109111 101109377 101110434 101110693 105614315 106990122 114108656
BTAX: 128058197 128058202 128058203 128058208 128058211 128058212 128058213 128058216
ODA: 120860627 120868601 120869467 120869469 120869471
CCAD: 122447956 122447958 122447959 122448269 122448454 122448455 122448456 122448511 122448512
MBEZ: 129547517 129555459 129559457 129559483 129559564 129559569 129559578 129559602 129559618 129559630 129559646
SSC: 654406(AKR1CL1) 733634(AKR1C1) 733635 733694(AKR1C1)
CFR: 102511678 116656624 116661570
CBAI: 105074137 105074417 105074427 105074728
CDK: 105104488 105104489 105105880
VPC: 102531609 102541232 102541486
BACU: 103002145 103003050
BMUS: 118891073 118891271
LVE: 103069218
OOR: 101273575 101281536
DLE: 111170128 111170129
PCAD: 102978533
PSIU: 116748968 116749098
NASI: 112407550 112407551
ECB: 100057212 100070491 100070501 100070509 100070616 111771771 111771772
EPZ: 103541472 103541473 103542048
EAI: 106824650 106827241 106827468 106846832 106846833 106846834 123281999
MYB: 102254990 102255491
MYD: 102751586 102763642
MMYO: 118672630 118672665
MLF: 102421358 102428982
MDT: 132215226 132215243
PKL: 118702292 118702295
EFUS: 103300835 103300840
MNA: 107542430 107542432
DRO: 112321159 112323007
SHON: 118977133
AJM: 119057712
PDIC: 114492418
PHAS: 123824859 123831227(AKR1C8)
MMF: 118632067 118632135
PPAM: 129084610 129084627
HAI: 109378613
PALE: 102889546
PGIG: 120608988
PVP: 105299187
MJV: 108384939 108393830 108407235 108407237 108407238
TOD: 119244650 119245260
SARA: 101543981 101545704 101551007 101551999 101555320 101555749
SETR: 126013285
LAV: 100659630 100659914
TMU: 101342771 101360332
ETF: 101653259 101653576
DNM: 101428157 101433437
OAA: 100085065 100085983
PSS: 102446010 102446253 102446483
CMY: 102946053 119563672
CCAY: 125625831
DCC: 119843778 119849865
CPIC: 101940001 101940260 101940524
TST: 117882842
CABI: 116815619
MRV: 120395343 120395491 120395494 120395542
PVT: 110070400 110071420 110088827
PMUA: 114590236 114604979 114604980 114604981 114605230 114605592
PRAF: 128421905 128421906 128421907 128421908 128421909 128422029
ZVI: 118090693 118090694 118090915
GJA: 107108026
EMC: 129335705
XLA: 100049750(XB5895996.L) 443571(akr1c3.L)
XTR: 100127714(akr1c1) 100490956 100494522 101733893 116406435 116409681 734139 779627(akr1c3)
NPR: 108789947 108789949 108799287 108799288 108799289 108799290 108799291
RTEM: 120921832 120932840
CPLA: 122559456
HOC: 132825023
PPYR: 116168970
DMK: 116918341
PMEO: 129593135
PVUL: 126823863 130010387
PMAX: 117329343 117329344 117331065
MCAF: 127727738
MMER: 123536211
RGL: CS053_01735
PRE: PCA10_43660
PFUW: KF707C_11730 KF707C_11870
PPUU: PputUW4_01679
PKC: PKB_4320
PFZ: AV641_10575
PPSY: AOC04_07875
PSET: THL1_4408
PSIL: PMA3_11580
PKE: DLD99_14670
PUM: HGP31_20975
PPSH: G5J76_13530
PLAL: FXN65_05815 FXN65_21130
PAZE: KSS91_19200
PTAE: NCTC10697_02065
PCAV: D3880_17455
PPHN: HU825_14715
PIZ: LAB08_R40780
PSHS: JJN09_05505
PLAU: I0D68_06085
PSKP: KU43P_19170
SDEG: GOM96_01720
HARR: HV822_17940
PPHA: BVH74_17925
HASM: QAO71_12395
PALI: A3K91_2273
PSYP: E5677_02060
SPL: Spea_2173
SHL: Shal_2144
CBER: B5D82_11215
PRR: AT705_22580
PVB: J5X90_19405
PSYM: J1N51_11265
SNAN: I6N98_05660
ZAL: AZF00_07095
OSG: BST96_18245
MAGA: Mag101_11180 Mag101_17580
HJA: BST95_16580
HALC: EY643_05560
KIM: G3T16_08455
AFUS: EYZ66_13070
PAQM: E0F26_07275
ASIP: AQUSIP_13610(cpnA_2)
LCJ: NCTC11976_00397(phaB_1)
FCF: FNFX1_1204
FPH: Fphi_0049
FPT: BZ13_56
FPI: BF30_220
FPM: LA56_250
FPX: KU46_1333
FPZ: LA55_1285
FPJ: LA02_1545
FRT: F7308_1194
FRF: LO80_02190
FRX: F7310_06325
FAD: CDH04_04000
FMI: F0R74_04375
FNN: FSC774_04745
FSR: KQR59_05790
OAI: OLEAN_C32440
MSEC: LN244_04840
MRZ: KDW95_00835
BSAN: CHH28_02370
NIK: F5I99_08975
EMP: EZMO1_1333(hsd)
SDF: ACG33_10715 ACG33_10795
SOK: D0B54_05265
SINI: GT972_08470
FCE: JN531_005460
RPJ: N234_25135
RIN: ACS15_4335 ACS15_4391
REH: H16_B0642(h16_B0642) H16_B0649(h16_B0649)
CNC: CNE_2c05880 CNE_2c05960 CNE_BB1p04020
CUH: BJN34_26905 BJN34_30930
REU: Reut_A1545 Reut_A1552
CTI: RALTA_B0491
CBW: RR42_s2341
COX: E0W60_08155 E0W60_08190
CUK: KB879_20650 KB879_20685 KB879_34810
CNAN: A2G96_30315 A2G96_30320
BUR: Bcep18194_B1514
BCT: GEM_4149
BCEP: APZ15_31395
BPYR: ABD05_28030
BCON: NL30_04370
BDF: WI26_20980
BTEI: WS51_05535
BSTL: BBJ41_21110
BANN: JFN94_25445
BARI: NLX30_30410
BAEN: L3V59_21505
BURK: DM992_32810
BFN: OI25_4612
PBRY: NDK50_32995
PPAI: E1956_37105
PVE: UC34_06900
CABA: SBC2_48780
CTT: CtCNB1_1764
CTES: O987_11065
CRJ: QMY55_09630
DIH: G7047_09040 G7047_10950
MPT: Mpe_A0884
METP: C1M51_13620
SMIO: CATMQ487_31550(fabG3)
DOE: DENOEST_3109 DENOEST_3547(cpnA)
AZI: AzCIB_1461
AZD: CDA09_09700
THU: AC731_008840
THAU: C4PIVTH_4327
THK: CCZ27_19355
THAG: CKCBHOJB_02373
MESJ: MJ8_05730
MRD: Mrad2831_6397
MTEA: DK419_00405
MIV: C4E04_06100
RHZ: RHPLAN_31970
METG: HT051_00245
THD: BHV28_12810
CAUL: KCG34_11925 KCG34_11965
OAT: OAN307_c19740
TGL: HFZ77_15250
PLIA: E4191_06175
DAA: AKL17_3498
PSEB: EOK75_03975
POZ: I0K15_01515
NAR: Saro_3532 Saro_3545
NPP: PP1Y_AT13638 PP1Y_Mpl5490
NRE: BES08_24625 BES08_24820
NOV: TQ38_005795 TQ38_017245 TQ38_022035 TQ38_023650
NOT: C7W88_19500 C7W88_19950
NGF: FRF71_08380 FRF71_08390 FRF71_10150
NOG: GKE62_04925 GKE62_06540 GKE62_06550
NOL: NSDW_20670 NSDW_25180 NSDW_26920
SPHK: SKP52_13580
SMAZ: LH19_04035
SPHQ: BWQ93_03585
SWI: Swit_2259
SPHD: HY78_14230 HY78_22845 HY78_22850
SPHI: TS85_08785
SPAN: AWL63_11370 AWL63_24005
SKR: BRX40_00695
SPHA: D3Y57_18050
SJP: SJA_C1-03930
SINB: SIDU_16905
SYB: TZ53_04155
SPMI: K663_17776 K663_18116
SPHR: BSY17_3924 BSY17_543
SHYD: CJD35_00570 CJD35_06880
SCLO: SCLO_1019010
SBAR: H5V43_14105
SAMI: SAMIE_1032770
SPPH: KFK14_08000 KFK14_08870 KFK14_13450 KFK14_21620
CIJ: WG74_05585
SPHG: AZE99_02190 AZE99_02220 AZE99_02570 AZE99_05050
SFLA: SPHFLASMR4Y_01233(benD) SPHFLASMR4Y_01334(benD) SPHFLASMR4Y_01377(benD) SPHFLASMR4Y_01860(benD) SPHFLASMR4Y_01932(benD) SPHFLASMR4Y_01938(benD)
SPHY: CHN51_02990 CHN51_03345 CHN51_03375 CHN51_17560 CHN51_18065
BLAS: BSY18_620
BFW: B5J99_12325
SPHJ: BSL82_07570 BSL82_07605 BSL82_14320
PARJ: J4G78_04415 J4G78_06985 J4G78_13315 J4G78_13345 J4G78_16400 J4G78_17660
PHAO: HF685_08370 HF685_13350 HF685_13380 HF685_15840
SMIC: SmB9_08780 SmB9_08790
SAND: H3309_10155 H3309_11070
ALH: G6N82_09480 G6N82_09490
ARUE: QQX03_02685 QQX03_02695
CMAN: A9D14_16350 A9D14_16785
ELQ: Ga0102493_111116 Ga0102493_111118 Ga0102493_112074
ERF: FIU90_01575(fabG1) FIU90_01585
PNS: A9D12_03500
ERYT: KDC96_13830 KDC96_13840
PORL: BG023_112375 BG023_11266 BG023_11268
PHZ: CHX26_01065 CHX26_01075 CHX26_13090
POT: E2E27_02035
PORC: CBR61_00700 CBR61_00710 CBR61_13160
NTD: EGO55_06220 EGO55_06680 EGO55_06825
CAEN: K5X80_13060
GDI: GDI2584
GDJ: Gdia_0818
KNA: B0W47_14495
KOI: LV478_10085
SHUM: STHU_19500
SVC: STVA_17970
NCB: C0V82_02450 C0V82_25770
RCE: RC1_0549
TXI: TH3_02810
THAC: CSC3H3_03145
THAR: T8K17_19965
SNEA: NBZ79_18740
GME: Gmet_2217
MSD: MYSTI_00848
MFB: MFUL124B02_04805
MLAN: JY572_22295
CCX: COCOR_00721
CFUS: CYFUS_005449
LPAR: FAM21731_00863
OOE: OEOE_0242
OEN: DSM07_06745
OSI: DLJ48_04325
VMA: VAB18032_22275
CEP: Cri9333_2499
PUV: PUV_09390
 » show all
Reference
1  [PMID:14214322]
  Authors
DAHM K, BREUER H.
  Title
[PRECIPITATION OF A 17-BETA-HYDROXYSTEROID:NAD(P) OXIDOREDUCTASE FROM THE RAT ADRENAL GLAND.]
  Journal
Hoppe Seylers Z Physiol Chem 336:63-8 (1964)
DOI:10.1515/bchm2.1964.336.1.63
Reference
2  [PMID:13549484]
  Authors
LYNN WS Jr, BROWN RH.
  Title
The conversion of progesterone to androgens by testes.
  Journal
J Biol Chem 232:1015-30 (1958)
Reference
3  [PMID:13295221]
  Authors
MARCUS PI, TALALAY P.
  Title
Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases.
  Journal
J Biol Chem 218:661-74 (1956)
Reference
4  [PMID:193845]
  Authors
Schultz RM, Groman EV, Engel LL
  Title
3(17)beta-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms.
  Journal
J Biol Chem 252:3775-83 (1977)
Reference
5  [PMID:13129261]
  Authors
TALALAY P, DOBSON MM.
  Title
Purification and properties of a beta-hydroxysteroid dehydrogenase.
  Journal
J Biol Chem 205:823-37 (1953)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.51
IUBMB Enzyme Nomenclature: 1.1.1.51
ExPASy - ENZYME nomenclature database: 1.1.1.51
UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.51
BRENDA, the Enzyme Database: 1.1.1.51
CAS: 9015-81-0
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