KEGG ORTHOLOGY: K04119

ORTHOLOGY: K04119

Entry

K04119                      KO

Symbol

AKR1C3

Name

aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]

Pathway

map00140

Steroid hormone biosynthesis

map00590

Arachidonic acid metabolism

map00790

Folate biosynthesis

map01100

Metabolic pathways

map04913

Ovarian steroidogenesis

map05208

Chemical carcinogenesis - reactive oxygen species

Module

M00976

C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone

M00977

C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone

Reaction

R01836

testosterone:NAD+ 17-oxidoreductase

R01838

testosterone:NADP+ 17-oxidoreductase

R02352

estradiol-17beta:NAD+ 17-oxidoreductase

R02353

estradiol-17beta:NADP+ 17-oxidoreductase

R02799

11-epi-prostaglandin F2alpha:NADP+ 11-oxidoreductase

R03406

androst-5-ene-3beta,17beta-diol:NAD+ oxidoreductase

R03407

androst-5-ene-3beta,17beta-diol:NADP+ oxidoreductase

R08955

3alpha,21-dihydroxy-5alpha-pregnan-20-one:NADP+ 3-oxidoreductase (A-specific)

R08957

3alpha-hydroxy-5alpha-pregnan-20-one:NADP+ 3-oxidoreductase (A-specific)

R08960

5alpha-pregnane-3alpha,20alpha-diol:NADP+ oxidoreductase (A-specific)

R11763

6-(1'-hydroxy-2'-oxopropyl)-tetrahydropterin:NADP+ oxidoreductase

R13039

R13219

androstan-3alpha,17beta-diol:NADP+ 17-oxidoreductase

R13220

dihydrotestosterone:NADP+ 17-oxidoreductase

R13221

dihydrotestosterone:NAD+ 17-oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K04119  AKR1C3; aldo-keto reductase family 1 member C3
   00590 Arachidonic acid metabolism
    K04119  AKR1C3; aldo-keto reductase family 1 member C3
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K04119  AKR1C3; aldo-keto reductase family 1 member C3
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K04119  AKR1C3; aldo-keto reductase family 1 member C3
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K04119  AKR1C3; aldo-keto reductase family 1 member C3
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.51  3(or 17)beta-hydroxysteroid dehydrogenase
     K04119  AKR1C3; aldo-keto reductase family 1 member C3
    1.1.1.188  prostaglandin-F synthase
     K04119  AKR1C3; aldo-keto reductase family 1 member C3
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     K04119  AKR1C3; aldo-keto reductase family 1 member C3
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     K04119  AKR1C3; aldo-keto reductase family 1 member C3

Other DBs

GO:	0030283 0047017 0047026

Genes

HSA:	8644(AKR1C3)

PTR:	100612718(AKR1C3) 100612887 746545

PPS:	100971300 100986388(AKR1C3) 100987632 100988315

GGO:	101144878(AKR1C3) 101147265(AKR1C8) 101152195

PON:	100174617(AKR1C3) 100432652 100461633 100462259

PPYG:

129006137 129006869 129006873 129006874(AKR1C8)

NLE:	100593325 100604844 100606512

HMH:	116457717 116460197(AKR1C8)

SSYN:

129491831 129491837 129491838

MCC:	100430336 711440 722485 722496

MCF:	102116465 102142023(HSD17B5) 102143072 102144231

MTHB:

126963005 126963008 126963422

MNI:	105490778 105490780 105490783 105494391 112428206

CSAB:

103237812 103237813 103237816

CATY:

105587690 105597446 105597481

PANU:

100997485 101022585 101024707

TGE:	112631307 112631750

MLEU:

105532496 105535734 105535762

RRO:	104674747 104678924

RBB:	108521036 108532990

TFN:	117082052 117082118 117083437

PTEH:

111528130 111528985 113224919

CANG:

105521700 105521704

CJC:	100406962 100409025 100409384

SBQ:	101041594 101042225 101049957

CIMI:

108285106 108292323 108292357

ANAN:

105710839 105710887 105710891

CSYR:

103261879 103261880 103261882 103261883 103263298 103263300

MMUR:

105858219 105858220 105858221 105858224

LCAT:

123623042 123623043 123623044 123623047

PCOQ:

105826891 105826910 105826913

OGA:	100942491 100967071

MCAL:

110308148

MPAH:

110333839 110333848

RNO:	361267(Akr1c15)

MCOC:

116081731

ANU:

117713832

MUN:

110560700

CGE:	100768090 100768376

MAUA:

101841267

PROB:

127229800

PLEU:

114708096

MORG:

121432600 121432606 121432658 121432668

MFOT:

126501679 126501680 126501681 126506800

AAMP:

119816160 119816243 119826549

NGI:	103725884 103725890 103725892 103746652

HGL:

101702106

CPOC:

100727454

CCAN:

109678869 109680334 109680990

DSP:

PLOP:

NCAR:

OCU:

OPI:	101524567 101525842 101526664 101526901 101527313 101527569 101527977

TUP:	102478063 102478495 102491222 102491650

GVR:	103602898 103610229 103610426

CFA:	497070(AKR1C3)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:	123802294(AKR1C8)

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:	122891768(AKR1C4)

ORO:	101377633 101379669

EJU:

114217720

ZCA:

113921662

MLX:	118021623 118021905

LWW:	102748666 102748964

FCA:	100510801(AKR1C3)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	100139386(20ALPHA-HSD) 112441538 112449293 282138(AKR1C4) 506594 527068 538060 617917(AKR1C3) 782884

BOM:	102267155 102269337 102271453 102271733 102272308 102272594 102272882 102273443 102283454 102284205

BIU:	109567627 109568074 109568076 109568077 109568079 109568080 109568087

BBUB:

102389138 102395293 102395635 102396460 102396772 102400645 102404780 102415234 102416534

BBIS:

104985980 104985985 104985990 104985991 104985992 104985994 104985995 104985998 104985999 104986133

CHX:	102176340 102176622 102177638 102186942 102187204 102187504 102187932 102188418 102188684 102189109 102189495 102190498

OAS:	101107119 101107541 101107809 101109111 101109377 101110434 101110693 105614315 106990122 114108656

BTAX:

128058197 128058202 128058203 128058208 128058211 128058212 128058213 128058216

ODA:	120860627 120868601 120869467 120869469 120869471

CCAD:

122447956 122447958 122447959 122448269 122448454 122448455 122448456 122448511 122448512

MBEZ:

129547517 129555459 129559457 129559483 129559564 129559569 129559578 129559602 129559618 129559630 129559646

SSC:	654406(AKR1CL1) 733634(AKR1C1) 733635 733694(AKR1C1)

CFR:	102511678 116656624 116661570

CBAI:

105074137 105074417 105074427 105074728

CDK:	105104488 105104489 105105880

VPC:	102531609 102541232 102541486

BACU:

103002145 103003050

BMUS:

118891073 118891271

LVE:

103069218

OOR:	101273575 101281536

DLE:	111170128 111170129

PCAD:

102978533

PSIU:

116748968 116749098

NASI:

112407550 112407551

ECB:	100057212 100070491 100070501 100070509 100070616 111771771 111771772

EPZ:	103541472 103541473 103542048

EAI:	106824650 106827241 106827468 106846832 106846833 106846834 123281999

MYB:	102254990 102255491

MYD:	102751586 102763642

MMYO:

118672630 118672665

MLF:	102421358 102428982

MDT:	132215226 132215243

PKL:	118702292 118702295

EFUS:

103300835 103300840

MNA:	107542430 107542432

DRO:	112321159 112323007

SHON:

118977133

AJM:

119057712

PDIC:

114492418

PHAS:

123824859 123831227(AKR1C8)

MMF:	118632067 118632135

PPAM:

HAI:

PALE:

PGIG:

PVP:

MJV:	108384939 108393830 108407235 108407237 108407238

TOD:	119244650 119245260

SARA:

101543981 101545704 101551007 101551999 101555320 101555749

SETR:

126013285

LAV:	100659630 100659914

TMU:	101342771 101360332

ETF:	101653259 101653576

DNM:	101428157 101433437

OAA:	100085065 100085983

PSS:	102446010 102446253 102446483

CMY:	102946053 119563672

CCAY:

125625831

DCC:	119843778 119849865

CPIC:

101940001 101940260 101940524

TST:

117882842

CABI:

116815619

MRV:	120395343 120395491 120395494 120395542

PVT:	110070400 110071420 110088827

PMUA:

114590236 114604979 114604980 114604981 114605230 114605592

PRAF:

128421905 128421906 128421907 128421908 128421909 128422029

ZVI:	118090693 118090694 118090915

GJA:

107108026

EMC:

129335705

XLA:	100049750(XB5895996.L) 443571(akr1c3.L)

XTR:	100127714(akr1c1) 100490956 100494522 101733893 116406435 116409681 734139 779627(akr1c3)

NPR:	108789947 108789949 108799287 108799288 108799289 108799290 108799291

RTEM:

CPLA:

HOC:

PPYR:

DMK:

PMEO:

PVUL:

PMAX:

117329343 117329344 117331065

MCAF:

127727738

MMER:

123536211

» show all

Reference

PMID:7650035

Authors

Khanna M, Qin KN, Wang RW, Cheng KC

Title

Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases.

Journal

J Biol Chem 270:20162-8 (1995)
DOI:10.1074/jbc.270.34.20162

Sequence

[hsa:8644]

Reference

PMID:15087468

Authors

Qiu W, Zhou M, Labrie F, Lin SX

Title

Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: critical androgen regulation in human peripheral tissues.

Journal

Mol Endocrinol 18:1798-807 (2004)
DOI:10.1210/me.2004-0032

Reference

PMID:14979715

Authors

Komoto J, Yamada T, Watanabe K, Takusagawa F

Title

Crystal structure of human prostaglandin F synthase (AKR1C3).

Journal

Biochemistry 43:2188-98 (2004)
DOI:10.1021/bi036046x

Reference

PMID:11165022

Authors

Penning TM, Burczynski ME, Jez JM, Lin HK, Ma H, Moore M, Ratnam K, Palackal N

Title

Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3).

Journal

Mol Cell Endocrinol 171:137-49 (2001)
DOI:10.1016/S0303-7207(00)00426-3

Reference

PMID:20186052

Authors

Penning TM

Title

New frontiers in androgen biosynthesis and metabolism.

Journal

Curr Opin Endocrinol Diabetes Obes 17:233-9 (2010)
DOI:10.1097/MED.0b013e3283381a31

Reference

PMID:24189185

Authors

Rizner TL, Penning TM

Title

Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism.

Journal

Steroids 79:49-63 (2014)
DOI:10.1016/j.steroids.2013.10.012

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