KEGG   Cucumis melo (muskmelon): 103499691
Entry
103499691         CDS       T03195                                 
Name
(RefSeq) bifunctional dihydrofolate reductase-thymidylate synthase
  KO
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
Organism
cmo  Cucumis melo (muskmelon)
Pathway
cmo00240  Pyrimidine metabolism
cmo00670  One carbon pool by folate
cmo00790  Folate biosynthesis
cmo01100  Metabolic pathways
cmo01232  Nucleotide metabolism
cmo01240  Biosynthesis of cofactors
Module
cmo_M00126  Tetrahydrofolate biosynthesis, GTP => THF
cmo_M00938  Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP
Brite
KEGG Orthology (KO) [BR:cmo00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    103499691
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    103499691
   00670 One carbon pool by folate
    103499691
Enzymes [BR:cmo01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     103499691
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     103499691
SSDB
Motif
Pfam: Thymidylat_synt DHFR_1
Other DBs
NCBI-GeneID: 103499691
NCBI-ProteinID: XP_050935632
LinkDB
Position
11:3973771..3980397
AA seq 528 aa
MAADPLTISNGIANVNSLPDPRRTYQVVVAATENLGIGKDGKLPWRLPSDLKFFKNITTT
TSDPGKRNAILMGRKTWESLPAEHRPLPGRLNVVLTRSGSFDIATVENVIICGSIMSALE
LLAASPYCLSIEKVFVIGGGEILREAMNAPECDAVHITEIETNIECDTFIPAIDKSMFQP
WYSSFPVVENNLRYSFNSYVRVRSSAELPIDQNNGLVSHNKPDFSNIEAKKFSFLPKEIF
ERHEEHLYLKLVQEIISDGIPKDDRTGTGTLSKFGCQMRYNLRKTFPLLTTKALFWRGVV
EELLWFISGSTNAKVLQEKGIHIWDGNASRDYLDSIGLREREEGDLGPVYGFQWRHFGAR
YTDMHADYTGQGFDQLLDVINKIKNNPDDRRIILSAWNPSDLKLMALPPCHMFSQFYVAN
GELSCQMYQRSADMGLGVPFNIASYALLTCMIAHVCGLARGDFIHVIGDAHVYRTHVRPL
QEQLQKLPKPFPILKINPEKKDIDSFVADDFELTGYDPHVKIAMKMAV
NT seq 1587 nt   +upstreamnt  +downstreamnt
atggccgctgatcctttgacaatttctaatggcattgccaatgtcaattcactacctgat
ccacggaggacttatcaagttgttgtagctgctactgaaaatttgggtatcggtaaggat
gggaaattaccatggaggttgccttctgatctcaagttttttaaaaacataaccacaaca
acatcagatcctgggaaaaggaatgcaattctaatgggtcgtaaaacatgggagagtctt
cctgccgagcatcgaccactacctggtcgcctgaatgttgttctgactcgttctggaagt
tttgacattgcaactgttgaaaatgttataatatgtggtagtataatgtctgctttggaa
ttattagcagcttctccttactgtttgtcaattgagaaggtgtttgttataggtggtggt
gaaatattaagggaagctatgaatgcccctgaatgtgatgctgtccacattactgaaatt
gagacaaatattgaatgtgacaccttcataccagctattgataagtcgatgtttcaacca
tggtactcatcttttcctgtggttgaaaataacttgcgatattcgtttaatagttatgtt
cgtgtgaggagctcagctgaacttcccattgatcagaacaatggtttggtctctcataac
aagcctgacttttctaacattgaagctaagaagttttctttcctacctaaggagattttc
gagaggcatgaggagcacttgtacctaaaacttgttcaagaaatcatctcagatggtatt
cctaaggatgatagaacaggaacaggtactttgtcaaaatttggttgccagatgcggtac
aacttgcgcaagacttttccactgcttacaactaaggcattattctggcgaggggtggtt
gaagaacttctttggttcattagtggttcaaccaatgcaaaggttcttcaggagaaaggc
attcatatatgggatggcaacgcatccagagattacctcgatagtatcggtttaagagaa
agggaggaaggtgacttgggacctgtatatgggttccagtggcgacactttggtgctagg
tatacggacatgcatgctgactatactggtcaaggatttgatcagttgctagatgttatt
aacaagataaaaaataatcctgatgaccggaggatcattctttctgcatggaatccatct
gatctcaaactgatggcacttcctccttgccacatgttctctcagttttacgttgcaaat
ggggagttatcatgtcaaatgtatcagcgttctgctgacatgggccttggtgttccattt
aatattgcgtcatatgctcttctgacttgcatgattgctcatgtttgtggtcttgctcga
ggtgacttcatacatgtgattggagatgctcatgtttaccgtactcatgtgaggccattg
caggaacaacttcagaaacttcccaaacccttccctattttgaagataaatcccgagaag
aaggatattgattcttttgtggcagatgattttgaactaactggttatgaccctcatgtg
aagatagcaatgaaaatggcagtatag

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