Entry Name IgSF CAM signaling - Camellia sinensis (tea plant)
Description Immunoglobulin superfamily cell adhesion molecules (IgSF CAMs) are cell surface proteins that mediate calcium-independent adhesion via their Ig-like domains. These extracellular regions commonly form homophilic interactions with similar molecules on adjacent cells but can also bind heterophilically to various other molecular partners. Their intracellular tails associate with cytoskeletal and adaptor proteins, linking external adhesion events to intracellular signaling. Through these mechanisms, IgSF CAMs play key roles in both normal physiological regulation and disease processes such as cancer development.
Class Environmental Information Processing; Signaling molecules and interactionBRITE hierarchy
Pathway map Organism Camellia sinensis (tea plant) [GN:
csin ]
Gene Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C04911 D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04927 N-Acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
Reference Authors Leshchyns'ka I, Sytnyk V
Title Reciprocal Interactions between Cell Adhesion Molecules of the Immunoglobulin Superfamily and the Cytoskeleton in Neurons.
Journal Reference Authors Kalafatakis I, Savvaki M, Velona T, Karagogeos D
Title Implication of Contactins in Demyelinating Pathologies.
Journal Reference Authors Gao Y, Kong L, Liu S, Liu K, Zhu J
Title Impact of Neurofascin on Chronic Inflammatory Demyelinating Polyneuropathy via Changing the Node of Ranvier Function: A Review.
Journal Reference Authors Pollerberg GE, Thelen K, Theiss MO, Hochlehnert BC
Title The role of cell adhesion molecules for navigating axons: density matters.
Journal Reference Authors Gennarini G, Bizzoca A, Picocci S, Puzzo D, Corsi P, Furley AJW
Title The role of Gpi-anchored axonal glycoproteins in neural development and neurological disorders.
Journal Reference Authors Raasakka A, Kursula P
Title Flexible Players within the Sheaths: The Intrinsically Disordered Proteins of Myelin in Health and Disease.
Journal Reference Authors Bradford D, Cole SJ, Cooper HM
Title Netrin-1: diversity in development.
Journal Reference Authors Boyer NP, Gupton SL
Title Revisiting Netrin-1: One Who Guides (Axons).
Journal Reference Authors Tong M, Jun T, Nie Y, Hao J, Fan D
Title The Role of the Slit/Robo Signaling Pathway.
Journal Reference Authors Bisiak F, McCarthy AA
Title Structure and Function of Roundabout Receptors.
Journal Reference Authors Feng L, Shu HP, Sun LL, Tu YC, Liao QQ, Yao LJ
Title Role of the SLIT-ROBO signaling pathway in renal pathophysiology and various renal diseases.
Journal Reference Authors Kostovska I, Trajkovska KT, Topuzovska S, Cekovska S, Labudovic D, Kostovski O, Spasovski G
Title Nephrinuria and podocytopathies.
Journal Reference Authors Guerra-Espinosa C, Jimenez-Fernandez M, Sanchez-Madrid F, Serrador JM
Title ICAMs in Immunity, Intercellular Adhesion and Communication.
Journal Reference Authors Turowski P, Adamson P, Greenwood J
Title Pharmacological targeting of ICAM-1 signaling in brain endothelial cells: potential for treating neuroinflammation.
Journal Reference Authors Farhangnia P, Ghomi SM, Mollazadehghomi S, Nickho H, Akbarpour M, Delbandi AA
Title SLAM-family receptors come of age as a potential molecular target in cancer immunotherapy.
Journal Reference Authors Li J, Fan T, Wang D, Xiao C, Deng Z, Cai W, Ji Y, Li C, He J
Title SLAMF receptors: key regulators of tumor progression and emerging targets for cancer immunotherapy.
Journal Reference Authors Ciesielska-Figlon K, Lisowska KA
Title The Role of the CD28 Family Receptors in T-Cell Immunomodulation.
Journal Reference Authors Garrido-Urbani S, Bradfield PF, Imhof BA
Title Tight junction dynamics: the role of junctional adhesion molecules (JAMs).
Journal Reference Authors Cornejo F, Cortes BI, Findlay GM, Cancino GI
Title LAR Receptor Tyrosine Phosphatase Family in Healthy and Diseased Brain.
Journal Reference Authors Um JW, Ko J
Title LAR-RPTPs: synaptic adhesion molecules that shape synapse development.
Journal Reference Authors Hermans D, Rodriguez-Mogeda C, Kemps H, Bronckaers A, de Vries HE, Broux B
Title Nectins and Nectin-like molecules drive vascular development and barrier function.
Journal Reference Authors Yadav SS, Srinivasan K, Sharma SS, Datusalia AK
Title Decoding the Nectin Interactome: Implications for Brain Development, Plasticity, and Neurological Disorders.
Journal KO pathway
