KEGG   PATHWAY: csin04519
Entry
csin04519                   Pathway                                
Name
Cadherin signaling - Camellia sinensis (tea plant)
Description
Cadherins constitute a large superfamily of calcium-dependent cell-cell adhesion proteins that serve as critical determinants of the timing and specificity of cell interactions, migration, and morphogenetic processes. Many cadherins mediate mechanical coupling between adjacent cells by organizing highly ordered junctional complexes. Beyond their adhesive roles, cadherins act as signaling platforms that influence cell motility, proliferation, and gene expression.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
csin04519  Cadherin signaling
csin04519

Organism
Camellia sinensis (tea plant) [GN:csin]
Gene
114255779  [KO:K06630]
114257639  [KO:K06171]
114258246  [KO:K05749]
114259550  [KO:K04392]
114259667  [KO:K06630]
114260269  [KO:K06630]
114260523  [KO:K06685]
114261719  [KO:K06630]
114262279  [KO:K18584]
114262825  [KO:K06630]
114264071  [KO:K06269] [EC:3.1.3.16]
114265410  [KO:K06630]
114266785  [KO:K06630]
114269028  [KO:K05758]
114271537  [KO:K05750]
114271568  [KO:K05752]
114273002  [KO:K04505] [EC:3.4.23.-]
114274140  [KO:K06269] [EC:3.1.3.16]
114274164  [KO:K06170]
114275505  [KO:K05757]
114276898  [KO:K06630]
114277777  [KO:K06630]
114279043  [KO:K06269] [EC:3.1.3.16]
114279323  [KO:K04392]
114279638  [KO:K06269] [EC:3.1.3.16]
114279818  [KO:K06630]
114279880  [KO:K04392]
114280220  [KO:K06630]
114280689  [KO:K06630]
114282376  [KO:K04392]
114283877  [KO:K06630]
114283907  [KO:K06630]
114284413  [KO:K06630]
114284433  [KO:K05756]
114285205  [KO:K17260]
114285325  [KO:K04368] [EC:2.7.12.2]
114285576  [KO:K04371] [EC:2.7.11.24]
114285823  [KO:K06630]
114285867  [KO:K06172]
114286903  [KO:K06269] [EC:3.1.3.16]
114288971  [KO:K17260]
114291617  [KO:K06269] [EC:3.1.3.16]
114292168  [KO:K05755]
114292523  [KO:K06630]
114292802  [KO:K05754]
114293416  [KO:K06685]
114294421  [KO:K06269] [EC:3.1.3.16]
114295419  [KO:K06630]
114296076  [KO:K06685]
114296431  [KO:K06269] [EC:3.1.3.16]
114296579  [KO:K06269] [EC:3.1.3.16]
114296742  [KO:K06269] [EC:3.1.3.16]
114297258  [KO:K04392]
114297770  [KO:K06630]
114297875  [KO:K06630]
114301667  [KO:K06685]
114301674  [KO:K06685]
114301734  [KO:K04392]
114302272  [KO:K06630]
114302940  [KO:K03083] [EC:2.7.11.26]
114303964  [KO:K04392]
114304524  [KO:K06685]
114305071  [KO:K06630]
114306769  [KO:K18584]
114307098  [KO:K04498] [EC:2.3.1.48]
114307974  [KO:K04498] [EC:2.3.1.48]
114309297  [KO:K05758]
114309402  [KO:K04392]
114309917  [KO:K06630]
114311386  [KO:K04392]
114311502  [KO:K06685]
114311556  [KO:K04505] [EC:3.4.23.-]
114311906  [KO:K04505] [EC:3.4.23.-]
114312843  [KO:K06630]
114314871  [KO:K06630]
114315782  [KO:K04498] [EC:2.3.1.48]
114317191  [KO:K04392]
114317467  [KO:K04392]
114319675  [KO:K06269] [EC:3.1.3.16]
114319735  [KO:K06630]
114320306  [KO:K04498] [EC:2.3.1.48]
114320828  [KO:K06269] [EC:3.1.3.16]
114321297  [KO:K04392]
114322868  [KO:K06685]
114322986  [KO:K06630]
114323058  [KO:K04505] [EC:3.4.23.-]
114323647  [KO:K06269] [EC:3.1.3.16]
114324052  [KO:K06630]
Reference
PMID:37255594
  Authors
Lin WH, Cooper LM, Anastasiadis PZ
  Title
Cadherins and catenins in cancer: connecting cancer pathways and tumor microenvironment.
  Journal
Front Cell Dev Biol 11:1137013 (2023)
DOI:10.3389/fcell.2023.1137013
Reference
PMID:37970977
  Authors
Mukherjee S, Goswami S, Dash S, Samanta D
  Title
Structural basis of molecular recognition among classical cadherins mediating cell adhesion.
  Journal
Biochem Soc Trans 51:2103-2115 (2023)
DOI:10.1042/BST20230356
Reference
PMID:16942809
  Authors
McCrea PD, Park JI
  Title
Developmental functions of the P120-catenin sub-family.
  Journal
Biochim Biophys Acta 1773:17-33 (2007)
DOI:10.1016/j.bbamcr.2006.06.009
Reference
PMID:23524961
  Authors
Hammers CM, Stanley JR
  Title
Desmoglein-1, differentiation, and disease.
  Journal
J Clin Invest 123:1419-22 (2013)
DOI:10.1172/JCI69071
Reference
PMID:34631720
  Authors
Muller L, Hatzfeld M, Keil R
  Title
Desmosomes as Signaling Hubs in the Regulation of Cell Behavior.
  Journal
Front Cell Dev Biol 9:745670 (2021)
DOI:10.3389/fcell.2021.745670
Reference
PMID:31028357
  Authors
Austin KM, Trembley MA, Chandler SF, Sanders SP, Saffitz JE, Abrams DJ, Pu WT
  Title
Molecular mechanisms of arrhythmogenic cardiomyopathy.
  Journal
Nat Rev Cardiol 16:519-537 (2019)
DOI:10.1038/s41569-019-0200-7
Reference
PMID:34765046
  Authors
Zhang J, Liang Y, Bradford WH, Sheikh F
  Title
Desmosomes: emerging pathways and non-canonical functions in cardiac arrhythmias and disease.
  Journal
Biophys Rev 13:697-706 (2021)
DOI:10.1007/s12551-021-00829-2
Reference
PMID:32694982
  Authors
Pancho A, Aerts T, Mitsogiannis MD, Seuntjens E
  Title
Protocadherins at the Crossroad of Signaling Pathways.
  Journal
Front Mol Neurosci 13:117 (2020)
DOI:10.3389/fnmol.2020.00117
Reference
PMID:21173574
  Authors
Kim SY, Yasuda S, Tanaka H, Yamagata K, Kim H
  Title
Non-clustered protocadherin.
  Journal
Cell Adh Migr 5:97-105 (2011)
DOI:10.4161/cam.5.2.14374
Reference
PMID:23481195
  Authors
Kahr I, Vandepoele K, van Roy F
  Title
Delta-protocadherins in health and disease.
  Journal
Prog Mol Biol Transl Sci 116:169-92 (2013)
DOI:10.1016/B978-0-12-394311-8.00008-X
Reference
PMID:33871677
  Authors
Liu S, Wang S, Zou L, Xiong W
  Title
Mechanisms in cochlear hair cell mechano-electrical transduction for acquisition of sound frequency and intensity.
  Journal
Cell Mol Life Sci 78:5083-5094 (2021)
DOI:10.1007/s00018-021-03840-8
Reference
PMID:22069509
  Authors
Caberlotto E, Michel V, de Monvel JB, Petit C
  Title
Coupling of the mechanotransduction machinery and F-actin polymerization in the cochlear hair bundles.
  Journal
Bioarchitecture 1:169-174 (2011)
DOI:10.4161/bioa.1.4.17532
Reference
PMID:29421162
  Authors
Vanniya S P, Srisailapathy CRS, Kunka Mohanram R
  Title
The tip link protein Cadherin-23: From Hearing Loss to Cancer.
  Journal
Pharmacol Res 130:25-35 (2018)
DOI:10.1016/j.phrs.2018.01.026
Reference
PMID:28603077
  Authors
Aviles EC, Goodrich LV
  Title
Configuring a robust nervous system with Fat cadherins.
  Journal
Semin Cell Dev Biol 69:91-101 (2017)
DOI:10.1016/j.semcdb.2017.06.001
Reference
PMID:27942226
  Authors
Zhang X, Liu J, Liang X, Chen J, Hong J, Li L, He Q, Cai X
  Title
History and progression of Fat cadherins in health and disease.
  Journal
Onco Targets Ther 9:7337-7343 (2016)
DOI:10.2147/OTT.S111176
Reference
PMID:32664346
  Authors
Zheng M, Jacob J, Hung SH, Wang J
  Title
The Hippo Pathway in Cardiac Regeneration and Homeostasis: New Perspectives for Cell-Free Therapy in the Injured Heart.
  Journal
Biomolecules 10:biom10071024 (2020)
DOI:10.3390/biom10071024
Reference
PMID:39768206
  Authors
Shi DL
  Title
Breaking Left-Right Symmetry by the Interplay of Planar Cell Polarity, Calcium Signaling and Cilia.
  Journal
Cells 13:cells13242116 (2024)
DOI:10.3390/cells13242116
KO pathway
ko04519   

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