KEGG   DRUG: フォリムタミグ
エントリ  
D12724                      Drug                                   
一般名   
フォリムタミグ;
Forimtamig (USAN/INN)
組成式   
C8551H13244N2300O2698S58
質量    
193175.3647
分子量   
193294.32
配列    
(A chain)
EVQLLESGGG LVQPGGSLRL SCAASGFTFS KYAMAWVRQA PGKGLEWVAS ISTGGVNTYY
ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCATHT GDYFDYWGQG TMVTVSSAST
KGPSVFPLAP SSKSTSGGTA ALGCLVEDYF PEPVTVSWNS GALTSGVHTF PAVLQSSGLY
SLSSVVTVPS SSLGTQTYIC NVNHKPSNTK VDEKVEPKSC DGGGGSGGGG SQAVVTQEPS
LTVSPGGTVT LTCGSSTGAV TTSNYANWVQ EKPGQAFRGL IGGTNKRAPG TPARFSGSLL
GGKAALTLSG AQPEDEAEYY CALWYSNLWV FGGGTKLTVL SSASTKGPSV FPLAPSSKST
SGGTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ SSGLYSLSSV VTVPSSSLGT
QTYICNVNHK PSNTKVDKKV EPKSCDKTHT CPPCPAPEAA GGPSVFLFPP KPKDTLMISR
TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN
GKEYKCKVSN KALGAPIEKT ISKAKGQPRE PQVYTLPPCR DELTKNQVSL WCLVKGFYPS
DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH
YTQKSLSLSP GK
(B chain)
EVQLLESGGG LVQPGGSLRL SCAASGFTFS KYAMAWVRQA PGKGLEWVAS ISTGGVNTYY
ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCATHT GDYFDYWGQG TMVTVSSAST
KGPSVFPLAP SSKSTSGGTA ALGCLVEDYF PEPVTVSWNS GALTSGVHTF PAVLQSSGLY
SLSSVVTVPS SSLGTQTYIC NVNHKPSNTK VDEKVEPKSC DKTHTCPPCP APEAAGGPSV
FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY
RVVSVLTVLH QDWLNGKEYK CKVSNKALGA PIEKTISKAK GQPREPQVCT LPPSRDELTK
NQVSLSCAVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLVSKL TVDKSRWQQG
NVFSCSVMHE ALHNHYTQKS LSLSPGK
(C chain)
EVQLLESGGG LVQPGGSLRL SCAASGFQFS SYAMNWVRQA PGKGLEWVSR IRSKYNNYAT
YYADSVKGRF TISRDDSKNT LYLQMNSLRA EDTAVYYCVR HTTFPSSYVS YYGYWGQGTL
VTVSSASVAA PSVFIFPPSD EQLKSGTASV VCLLNNFYPR EAKVQWKVDN ALQSGNSQES
VTEQDSKDST YSLSSTLTLS KADYEKHKVY ACEVTHQGLS SPVTKSFNRG EC
(D chain)
EIVLTQSPGT LSLSPGERAT LSCRASQSVS ISGINLMNWY QQKPGQQPKL LIYHASILAS
GIPDRFSGSG SGTDFTLTIS RLEPEDFAVY YCQQTRESPL TFGQGTRLEI KRTVAAPSVF
IFPPSDRKLK SGTASVVCLL NNFYPREAKV QWKVDNALQS GNSQESVTEQ DSKDSTYSLS
STLTLSKADY EKHKVYACEV THQGLSSPVT KSFNRGEC
(Disulfide bridge: A22-A96, A144-A200, A220-D218, A253-A321, A369-A425, A445-C232, A451-B226, A454-B229, A486-A546, A579-B34, A592-A650, B22-B96, B144-B200, B220-D'218, B261-B321, B367-B425, C22-C98, C152-C212, D23-D92, D138-D198, D'23-D'92, D'138-D'198)
  タイプ
Peptide
効能    
抗悪性腫瘍薬
  タイプ
二重特異性抗体
ターゲット 
GPRC5D [HSA:55507] [KO:K04621]
CD3E [HSA:916] [KO:K06451]
  パスウェイ
hsa04640  造血細胞系譜
hsa04658  Th1 および Th2 細胞の分化
hsa04659  Th17 細胞の分化
hsa04660  T 細胞シグナル伝達経路
階層分類  
ターゲットに基づく医薬品分類 [BR:jp08310]
 Gタンパク質共役受容体
  代謝型グルタミン酸受容体ファミリー
   オーファン GPRC5
    GPRC5D
     D12724  フォリムタミグ
 細胞表面分子とリガンド
  その他の細胞表面分子
   CD 分子
    CD3E
     D12724  フォリムタミグ
リンク   
CAS: 2649379-96-2
PubChem: 497621137
LinkDB    

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