KEGG   DISEASE: 肛門管癌
エントリ  
H00044                                                             
名称    
肛門管癌
概要    
Squamous cell carcinoma of the anal canal accounts for 1.5 per cent of all digestive system cancers in the USA, with an estimated 4,660 new cases and 660 deaths in 2006. Epidemiological and molecular-biology studies have now shown that sexually transmitted infection with human papillomavirus (HPV) is the most important aetiological agent. Human immunodeficiency virus (HIV) infection is also associated with anal cancer. HPV infection is transient in most immunocompetent individuals, but HIV-positive patients have evidence of persistent HPV infection within the anal canal. Current data suggest that mutations in p53, DCC and APC tumor suppressor genes contribute to the stepwise progression of anal squamous cell carcinoma in immunocompetent individuals.
カテゴリ  
がん
階層分類  
ヒト疾患 [BR:jp08402]
 がん
  消化器系のがん
   H00044  肛門管癌
ICD-11 による疾患分類 [BR:jp08403]
 02 腫瘍
  悪性腫瘍, ただしリンパ, 造血, 中枢神経系または関連組織の原発腫瘍を除く
   悪性腫瘍, 原発性と確定または推定されるもの, 明示された部位のもの, ただしリンパ, 造血, 中枢神経系, 関連組織を除く
    消化器の悪性腫瘍
     腸の悪性腫瘍
      2C00  肛門または肛門管の悪性腫瘍
       H00044  肛門管癌
関連パスウェイ
hsa05200  Pathways in cancer
hsa05165  Human papillomavirus infection
病因遺伝子 
p53 (mutation) [HSA:7157] [KO:K04451]
DCC (mutation) [HSA:1630] [KO:K06765]
APC (mutation) [HSA:324] [KO:K02085]
発癌物質  
Tobacco smoking and tobacco smoke
病原体   
Human papillomavirus type 16 [GN:T40087]
Human papillomavirus type 18 [GN:T40088]
治療薬   
組換え沈降4価ヒトパピローマウイルス様粒子ワクチン [DR:D10192]
リンク   
ICD-11: 2C00
ICD-10: C21
MeSH: D001005
文献    
PMID:16607677 (gene, carcinogen, tumor type)
  著者
Gervaz P, Hirschel B, Morel P.
  タイトル
Molecular biology of squamous cell carcinoma of the anus.
  雑誌
Br J Surg 93:531-8 (2006)
DOI:10.1002/bjs.5376
文献    
PMID:12947531 (gene, carcinogen)
  著者
Gervaz P, Allal AS, Villiger P, Buhler L, Morel P.
  タイトル
Squamous cell carcinoma of the anus: another sexually transmitted disease.
  雑誌
Swiss Med Wkly 133:353-9 (2003)
文献    
PMID:11281434 (carcinogen)
  著者
Severson J, Evans TY, Lee P, Chan T, Arany I, Tyring SK.
  タイトル
Human papillomavirus infections: epidemiology, pathogenesis, and therapy.
  雑誌
J Cutan Med Surg 5:43-60 (2001)
DOI:10.1177/120347540100500110
文献    
PMID:1311142 (carcinogen)
  著者
Daling JR, Sherman KJ, Hislop TG, Maden C, Mandelson MT, Beckmann AM, Weiss NS.
  タイトル
Cigarette smoking and the risk of anogenital cancer.
  雑誌
Am J Epidemiol 135:180-9 (1992)
DOI:10.1093/oxfordjournals.aje.a116270
文献    
PMID:17255774 (marker)
  著者
Owens SR, Greenson JK.
  タイトル
Immunohistochemical staining for p63 is useful in the diagnosis of anal squamous cell carcinomas.
  雑誌
Am J Surg Pathol 31:285-90 (2007)
DOI:10.1097/01.pas.0000213362.10756.d3
文献    
PMID:9372374 (marker)
  著者
Indinnimeo M, Reale MG, Cicchini C, Stazi A, Fiori E, Izzo P.
  タイトル
CEA, TPA, CA 19-9, SCC and CYFRA at diagnosis and in the follow-up of anal canal tumors.
  雑誌
Int Surg 82:275-9 (1997)
LinkDB    

» English version

DBGET integrated database retrieval system