KEGG   Homo sapiens (human): 1630
Entry
1630              CDS       T01001                                 
Symbol
DCC, CRC18, CRCR1, HGPPS2, IGDCC1, MRMV1, NTN1R1
Name
(RefSeq) DCC netrin 1 receptor
  KO
K06765  deleted in colorectal carcinoma
Organism
hsa  Homo sapiens (human)
Pathway
hsa04360  Axon guidance
hsa05200  Pathways in cancer
hsa05210  Colorectal cancer
Network
nt06231  Apoptosis
nt06260  Colorectal cancer
  Element
N00101  DCC-apoptotic pathway
N00102  Loss of DCC to DCC-apoptotic pathway
Disease
H00017  Esophageal cancer
H00020  Colorectal cancer
H00044  Cancer of the anal canal
H01287  Congenital mirror movements
H02450  Horizontal gaze palsy with progressive scoliosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    1630 (DCC)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1630 (DCC)
  09162 Cancer: specific types
   05210 Colorectal cancer
    1630 (DCC)
SSDB
Motif
Pfam: Neogenin_C fn3 I-set Ig_3 ig Ig_2 V-set Pur_ac_phosph_N C2-set_2 Interfer-bind Ig_4 Protocadherin FAM176 EphA2_TM V-set_CD47 CD34_antigen Ly49 TMEM154 Herpes_gE DUF4998
Other DBs
NCBI-GeneID: 1630
NCBI-ProteinID: NP_005206
OMIM: 120470
HGNC: 2701
Ensembl: ENSG00000187323
Pharos: P43146(Tbio)
UniProt: P43146 Q49AK4
Structure
LinkDB
Position
18:52340197..53535899
AA seq 1447 aa
MENSLRCVWVPKLAFVLFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLD
CSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEAS
LGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDL
TPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQL
YFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNV
TDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVP
TVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKP
AIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTT
QPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTS
PTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLA
YNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKI
RHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDL
DESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRY
YSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDL
STPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDT
TSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKP
RAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYF
RIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPI
GQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGK
RKGSQKDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGS
KSTSHSGQDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQ
YPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRSQSVSEGPTTQQPPMLPPSQPEH
SSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTPLLSQPGPTLPKTHVK
TASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSANVYEQDDLSEQMASLEGLMKQLN
AITGSAF
NT seq 4344 nt   +upstreamnt  +downstreamnt
atggagaatagtcttagatgtgtttgggtacccaagctggcttttgtactcttcggagct
tccttgttcagcgcgcatcttcaagtaaccggttttcaaattaaagctttcacagcactg
cgcttcctctcagaaccttctgatgccgtcacaatgcggggaggaaatgtcctcctcgac
tgctccgcggagtccgaccgaggagttccagtgatcaagtggaagaaagatggcattcat
ctggccttgggaatggatgaaaggaagcagcaactttcaaatgggtctctgctgatacaa
aacatacttcattccagacaccacaagccagatgagggactttaccaatgtgaggcatct
ttaggagattctggctcaattattagtcggacagcaaaagttgcagtagcaggaccactg
aggttcctttcacagacagaatctgtcacagccttcatgggagacacagtgctactcaag
tgtgaagtcattggggagcccatgccaacaatccactggcagaagaaccaacaagacctg
actccaatcccaggtgactcccgagtggtggtcttgccctctggagcattgcagatcagc
cgactccaaccgggggacattggaatttaccgatgctcagctcgaaatccagccagctca
agaacaggaaatgaagcagaagtcagaattttatcagatccaggactgcatagacagctg
tattttctgcaaagaccatccaatgtagtagccattgaaggaaaagatgctgtcctggaa
tgttgtgtttctggctatcctccaccaagttttacctggttacgaggcgaggaagtcatc
caactcaggtctaaaaagtattctttattgggtggaagcaacttgcttatctccaatgtg
acagatgatgacagtggaatgtatacctgtgttgtcacatataaaaatgagaatattagt
gcctctgcagagctcacagtcttggttccgccatggtttttaaatcatccttccaacctg
tatgcctatgaaagcatggatattgagtttgaatgtacagtctctggaaagcctgtgccc
actgtgaattggatgaagaatggagatgtggtcattcctagtgattattttcagatagtg
ggaggaagcaacttacggatacttggggtggtgaagtcagatgaaggcttttatcaatgt
gtggctgaaaatgaggctggaaatgcccagaccagtgcacagctcattgtccctaagcct
gctatcccaagctccagtgtcctcccttcggctcccagagatgtggtccctgtcttggtt
tccagccgatttgtccgtctcagctggcgcccacctgcagaagcgaaagggaacattcaa
actttcacggtctttttctccagagaaggtgacaacagggaacgagcattgaatacaaca
cagcctgggtcccttcagctcactgtgggaaacctgaagccagaagccatgtacaccttt
cgagttgtggcttacaatgaatggggaccgggagagagttctcaacccatcaaggtggcc
acacagcctgagttgcaagttccagggccagtagaaaacctgcaagctgtatctacctca
cctacctcaattcttattacctgggaaccccctgcctatgcaaacggtccagtccaaggt
tacagattgttctgcactgaggtgtccacaggaaaagaacagaatatagaggttgatgga
ctatcttataaactggaaggcctgaaaaaattcaccgaatatagtcttcgattcttagct
tataatcgctatggtccgggcgtctctactgatgatataacagtggttacactttctgac
gtgccaagtgccccgcctcagaacgtctccctggaagtggtcaattcaagaagtatcaaa
gttagctggctgcctcctccatcaggaacacaaaatggatttattaccggctataaaatt
cgacacagaaagacgacccgcaggggtgagatggaaacactggagccaaacaacctctgg
tacctattcacaggactggagaaaggaagtcagtacagtttccaggtgtcagccatgaca
gtcaatggtactggaccaccttccaactggtatactgcagagactccagagaatgatcta
gatgaatctcaagttcctgatcaaccaagctctcttcatgtgaggccccagactaactgc
atcatcatgagttggactcctcccttgaacccaaacatcgtggtgcgaggttatattatc
ggttatggcgttgggagcccttacgctgagacagtgcgtgtggacagcaagcagcgatat
tattccattgagaggttagagtcaagttcccattatgtaatctccctaaaagcttttaac
aatgccggagaaggagttcctctttatgaaagtgccaccaccaggtctataaccgatccc
actgacccagttgattattatcctttgcttgatgatttccccacctcggtcccagatctc
tccacccccatgctcccaccagtaggtgtacaggctgtggctcttacccatgatgctgtg
agggtcagctgggcagacaactctgtccctaagaaccaaaagacgtctgaggtgcgactt
tacaccgtccggtggagaaccagcttttctgcaagtgcaaaatacaagtcagaagacaca
acatctctaagttacacagcaacaggcctcaaaccaaacacaatgtatgaattctcggtc
atggtaacaaaaaacagaaggtccagtacttggagcatgactgcacatgccaccacgtat
gaagcagcccccacctctgctcccaaggacttgacagtcattactagggaagggaagcct
cgtgccgtcattgtgagttggcagcctcccttggaagccaatgggaaaattactgcttac
atcttattttataccttggacaagaacatcccaattgatgactggattatggaaacaatc
agtggtgataggcttactcatcaaatcatggatctcaaccttgatactatgtattacttt
cgaattcaagcacgaaattcaaaaggagtggggccactctctgatcctatcctcttcagg
actctgaaagtggaacaccctgacaaaatggctaatgaccaaggtcgtcatggagatgga
ggttattggccagttgatactaatttgattgatagaagcaccctaaatgagccgccaatt
ggacaaatgcaccccccgcatggcagtgtcactcctcagaagaacagcaacctgcttgtg
atcattgtggtcaccgttggtgtcatcacagtgctggtagtggtcatcgtggctgtgatt
tgcacccgacgctcttcagcccagcagagaaagaaacgggccacccacagtgctggcaaa
aggaagggcagccagaaggacctccgaccccctgatctttggatccatcatgaagaaatg
gagatgaaaaatattgaaaagccatctggcactgaccctgcaggaagggactctcccatc
caaagttgccaagacctcacaccagtcagccacagccagtcagaaacccaactgggaagc
aaaagcacctctcattcaggtcaagacactgaggaagcagggagctctatgtccactctg
gagaggtcgctggctgcacgccgagccccccgggccaagctcatgattcccatggatgcc
cagtccaacaatcctgctgtcgtgagcgccatcccggtgccaacgctagaaagtgcccag
tacccaggaatcctcccgtctcccacctgtggatatccccacccgcagttcactctccgg
cctgtgccattcccaacactctcagtggaccgaggtttcggagcaggaagaagtcagtca
gtgagtgaaggaccaactacccaacaaccacctatgctgcccccatctcagcctgagcat
tctagcagcgaggaggcaccaagcagaaccatccccacagcttgtgttcgaccaactcac
ccactccgcagctttgctaatcctttgctacctccaccaatgagtgcaatagaaccgaaa
gtcccttacacaccacttttgtctcagccagggcccactcttcctaagacccatgtgaaa
acagcctcccttgggttggctggaaaagcaagatcccctttgcttcctgtgtctgtgcca
acagcccctgaagtgtctgaggagagccacaaaccaacagaggattcagccaatgtgtat
gaacaggatgatctgagtgaacaaatggcaagtttggaaggactcatgaagcagcttaat
gccatcacaggctcagccttttaa

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