KEGG   DISEASE: 不眠症
エントリ  
H01609                                                             
名称    
不眠症
概要    
Insomnia is a common disorder with a prevalence of about 10% in the general population. The most common complaints related to insomnia are difficulty initiating sleep (sleep-onset insomnia), difficulty maintaining sleep due to prolonged nocturnal awakenings (sleep-maintenance insomnia), early morning awakenings, and excessive daytime sleepiness resulting from lack of sleep. Furthermore, insomnia is associated with an increased risk of anxiety and depression, suicidality, and cardiovascular diseases. Currently, cognitive behavioral therapy for insomnia (CBT-I) is recommended as first-line therapy. While behavioral therapies are effective for chronic insomnia in some patients, pharmacotherapy is frequently used when immediate short-term symptom relief is needed. The most effective pharmacologic therapies for insomnia are benzodiazepines, benzodiazepine-receptor agonists, melatonin-receptor agonists, and antidepressants.
カテゴリ  
神経系疾患
階層分類  
ICD-11 による疾患分類 [BR:jp08403]
 07 睡眠・覚醒の障害
  不眠症
   7A00  慢性不眠症
    H01609  不眠症
   7A01  短期不眠症
    H01609  不眠症
治療薬   
ブロモバレリル尿素 [DR:D01391]
トリクロホスナトリウム [DR:D00388]
フルラゼパム塩酸塩 [DR:D01408]
ニトラゼパム [DR:D00531]
フルニトラゼパム [DR:D01230]
エスタゾラム [DR:D00311]
トリアゾラム [DR:D00387]
ロルメタゼパム [DR:D01657]
ブロチゾラム [DR:D01744]
クアゼパム [DR:D00457]
ハロキサゾラム [DR:D01758]
フェノバルビタール [DR:D00506]
ペントバルビタールカルシウム [DR:D02253]
ゾピクロン [DR:D01372]
ゾルピデム酒石酸塩 [DR:D00706]
エスゾピクロン [DR:D02624]
リルマザホン塩酸塩水和物 [DR:D01564]
ラメルテオン [DR:D02689]
スボレキサント [DR:D10082]
レンボレキサント [DR:D11022]
ブドウ酒 [DR:D04961]
温経湯 [DR:D06919]
黄連解毒湯エキス [DR:D06924]
加味帰脾湯エキス [DR:D06929]
甘麦大棗湯 [DR:D06931]
帰脾湯 [DR:D06934]
桂枝加竜骨牡蛎湯 [DR:D06945]
柴胡加竜骨牡蛎湯 [DR:D06962]
柴胡桂枝乾姜湯エキス [DR:D06963]
三黄瀉心湯 [DR:D06967]
酸棗仁湯 [DR:D06968]
大柴胡湯エキス [DR:D07004]
大柴胡湯去大黄 [DR:D07005]
人参養栄湯 [DR:D07028]
半夏厚朴湯エキス [DR:D07032]
抑肝散エキス [DR:D07049]
抑肝散加陳皮半夏エキス [DR:D07050]
リンク   
ICD-11: 7A00 7A01
ICD-10: F51.0 G47.0
MeSH: D007319
文献    
  著者
Lancee J, van Straten A, Morina N, Kaldo V, Kamphuis JH
  タイトル
Guided Online or Face-to-Face Cognitive Behavioral Treatment for Insomnia: A Randomized Wait-List Controlled Trial.
  雑誌
Sleep 39:183-91 (2016)
DOI:10.5665/sleep.5344
文献    
  著者
Palagini L, Faraguna U, Mauri M, Gronchi A, Morin CM, Riemann D
  タイトル
Association between stress-related sleep reactivity and cognitive processes in insomnia disorder and insomnia subgroups: preliminary results.
  雑誌
Sleep Med 19:101-7 (2016)
DOI:10.1016/j.sleep.2015.10.020
文献    
  著者
Najib J
  タイトル
Eszopiclone, a nonbenzodiazepine sedative-hypnotic agent for the treatment of transient and chronic insomnia.
  雑誌
Clin Ther 28:491-516 (2006)
DOI:10.1016/j.clinthera.2006.04.014
文献    
  著者
Schoedel KA, Sun H, Sellers EM, Faulknor J, Levy-Cooperman N, Li X, Kennedy WP, Cha JH, Lewis NM, Liu W, Bondiskey P, McCrea JB, Panebianco DL, Troyer MD, Wagner JA
  タイトル
Assessment of the Abuse Potential of the Orexin Receptor Antagonist, Suvorexant, Compared With Zolpidem in a Randomized Crossover Study.
  雑誌
J Clin Psychopharmacol 36:314-23 (2016)
DOI:10.1097/JCP.0000000000000516
文献    
  著者
Cardinali DP, Golombek DA, Rosenstein RE, Brusco LI, Vigo DE
  タイトル
Assessing the efficacy of melatonin to curtail benzodiazepine/Z drug abuse.
  雑誌
Pharmacol Res 109:12-23 (2016)
DOI:10.1016/j.phrs.2015.08.016
文献    
  著者
Passarella S, Duong MT
  タイトル
Diagnosis and treatment of insomnia.
  雑誌
Am J Health Syst Pharm 65:927-34 (2008)
DOI:10.2146/ajhp060640
文献    
  著者
Morin CM, Edinger JD, Krystal AD, Buysse DJ, Beaulieu-Bonneau S, Ivers H
  タイトル
Sequential psychological and pharmacological therapies for comorbid and primary insomnia: study protocol for a randomized controlled trial.
  雑誌
Trials 17:118 (2016)
DOI:10.1186/s13063-016-1242-3
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